Document Detail


Hypogonadism, quadriceps weakness, and exercise intolerance in chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  16100014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: Circulating levels of testosterone and gonadotrophins of patients with chronic obstructive pulmonary disease (COPD) have never been compared with those of elderly men with normal pulmonary function. Moreover, the relationship of hypogonadism with quadriceps muscle weakness and exercise intolerance has been studied scarcely in men with COPD. OBJECTIVES: To compare circulating levels of hormones of the pituitary-gonadotrophic axis of men with COPD with those of age-matched control subjects. Moreover, to study the relationship of hypogonadism with quadriceps muscle force, 6-min walking distance, and systemic markers of inflammation in the patients. METHODS AND MEASUREMENTS: Circulating levels of follicle-stimulating hormone, luteinizing hormone, testosterone, and sex hormone-binding globulin were determined, and free testosterone was calculated in 78 patients (FEV1: 44 +/- 17% of the predicted values) and 21 control subjects. Moreover, quadriceps muscle force, 6-min walking distance, number of pack-yr, and systemic inflammation were determined. MAIN RESULTS: Follicle-stimulating hormone and luteinizing hormone were higher in the patients, whereas testosterone was lower (p < or = 0.05). The latter finding was also present in 48 non-steroid-using patients with normal blood gases. Low androgen status was significantly related to quadriceps muscle weakness (r = 0.48) and C-reactive protein (r = -0.39) in the patients, but not to exercise intolerance, the number of pack-yr, or increased circulating levels of interleukin 8 or soluble receptors of tumor necrosis factor alpha. CONCLUSIONS: In contrast to exercise intolerance, quadriceps muscle weakness is related to low circulating levels of testosterone in men with COPD.
Authors:
Monique Van Vliet; Martijn A Spruit; Geert Verleden; Ahmad Kasran; Erik Van Herck; Fabio Pitta; Roger Bouillon; Marc Decramer
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Publication Detail:
Type:  Journal Article     Date:  2005-08-11
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  172     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-26     Completed Date:  2006-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1105-11     Citation Subset:  AIM; IM    
Affiliation:
Respiratory Rehabilitation, University Hospital Gasthuisberg, Herestraat 49, B-3000, Leuven, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Aged
C-Reactive Protein / metabolism
Case-Control Studies
Exercise Tolerance / physiology*
Follicle Stimulating Hormone, Human / blood
Humans
Hypogonadism / blood,  complications*,  physiopathology
Immunoglobulin G / blood
Luteinizing Hormone / blood
Male
Middle Aged
Muscle Weakness / blood,  complications*,  physiopathology
Muscle, Skeletal / physiopathology
Pulmonary Disease, Chronic Obstructive / blood,  complications,  physiopathology*
Receptor, Nerve Growth Factor / blood
Receptors, Tumor Necrosis Factor / blood
Sex Hormone-Binding Globulin / metabolism
Testosterone / blood*
Chemical
Reg. No./Substance:
0/Follicle Stimulating Hormone, Human; 0/Immunoglobulin G; 0/Receptor, Nerve Growth Factor; 0/Receptors, Tumor Necrosis Factor; 0/Sex Hormone-Binding Globulin; 185243-69-0/TNFR-Fc fusion protein; 58-22-0/Testosterone; 9002-67-9/Luteinizing Hormone; 9007-41-4/C-Reactive Protein
Comments/Corrections
Comment In:
Am J Respir Crit Care Med. 2005 Nov 1;172(9):1069-70   [PMID:  16249319 ]

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