Document Detail

Hypoglycemic peripheral neuropathy in association with insulinoma: implication of glucopenia rather than hyperinsulinism. Case report and literature review.
MedLine Citation:
PMID:  6276647     Owner:  NLM     Status:  MEDLINE    
A syndrome of peripheral polyneuropathy associated with islet cell tumors and hypoglycemia has been reported in 28 patients. Despite varying features in these patients, the clinical characteristics of this syndrome are remarkably similar. These consist of the development of a sensorimotor neuropathy during a protracted course of recurrent severe hypoglycemia, related to underlying insulinoma. Cerebral symptoms dominate the clinical picture and a predominantly or entirely motor, distal and symmetric, peripheral neuropathy ensures. Upper limb involvement is more frequent, accompanied by severe weakness and distal wasting, usually without fasciculations. Painful distal paresthesias without objective sensory loss are characteristic. Direct relationship to a single hypoglycemic insult is often absent. This report describes the clinical features and laboratory investigation of a new case with this condition, reviews the literature and discusses the syndrome with special regard to the etiology.
J B Jaspan; R L Wollman; L Bernstein; A H Rubenstein
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Medicine     Volume:  61     ISSN:  0025-7974     ISO Abbreviation:  Medicine (Baltimore)     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-04-20     Completed Date:  1982-04-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985248R     Medline TA:  Medicine (Baltimore)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  33-44     Citation Subset:  AIM; IM    
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MeSH Terms
Adenoma, Islet Cell / blood*
Blood Glucose / metabolism
Hyperinsulinism / blood*
Hypoglycemia / blood*
Insulin / blood
Insulinoma / blood*,  pathology
Microscopy, Electron
Middle Aged
Muscular Atrophy / blood
Nerve Fibers, Myelinated / ultrastructure
Neural Conduction
Neuromuscular Diseases / blood
Pancreatic Neoplasms / blood*,  pathology
Peripheral Nervous System Diseases / blood*
Proinsulin / blood
Sural Nerve / pathology
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 9035-68-1/Proinsulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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