Document Detail


Hypoglycemic effect of fenfluramine in insulin-treated diabetics.
MedLine Citation:
PMID:  3514018     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In addition to its anorectic effect, fenfluramine has been demonstrated to decrease blood glucose levels in diabetics, independently of weight loss or the anorectic action. These studies have usually been performed in insulin-independent diabetics. We therefore undertook to investigate 8 non-insulin-dependent and 2 insulin-dependent patients receiving insulin, and noted a mean 21.1 +/- 3.8% decrease in blood glucose after 10 days of fenfluramine utilization. This parameter was diminished in all subjects in whom it had been elevated (greater than 120 mg/d1) during the placebo period of our double-blind, randomized study. Thus, fenfluramine apparently has the capacity to lower glucose in patients receiving insulin therapy.
Authors:
P Hamet; I Verdy; J L Chiasson; M Verdy
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical and investigative medicine. Médecine clinique et experimentale     Volume:  9     ISSN:  0147-958X     ISO Abbreviation:  Clin Invest Med     Publication Date:  1986  
Date Detail:
Created Date:  1986-05-05     Completed Date:  1986-05-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7804071     Medline TA:  Clin Invest Med     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  12-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Glucose / metabolism*
Clinical Trials as Topic
Diabetes Mellitus, Type 1 / drug therapy*
Diabetes Mellitus, Type 2 / drug therapy*
Female
Fenfluramine / therapeutic use*
Humans
Hypoglycemic Agents*
Insulin / therapeutic use
Male
Middle Aged
Grant Support
ID/Acronym/Agency:
AM 2199-07/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Hypoglycemic Agents; 11061-68-0/Insulin; 458-24-2/Fenfluramine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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