Document Detail

Hypoglycemic effect of fenfluramine in insulin-treated diabetics.
MedLine Citation:
PMID:  3514018     Owner:  NLM     Status:  MEDLINE    
In addition to its anorectic effect, fenfluramine has been demonstrated to decrease blood glucose levels in diabetics, independently of weight loss or the anorectic action. These studies have usually been performed in insulin-independent diabetics. We therefore undertook to investigate 8 non-insulin-dependent and 2 insulin-dependent patients receiving insulin, and noted a mean 21.1 +/- 3.8% decrease in blood glucose after 10 days of fenfluramine utilization. This parameter was diminished in all subjects in whom it had been elevated (greater than 120 mg/d1) during the placebo period of our double-blind, randomized study. Thus, fenfluramine apparently has the capacity to lower glucose in patients receiving insulin therapy.
P Hamet; I Verdy; J L Chiasson; M Verdy
Related Documents :
21358698 - Glucose dynamics and mechanistic implications of sglt2 inhibitors in animals and humans.
12469088 - Operative management of the frozen shoulder in patients with diabetes.
20469788 - Acquired reactive perforating collagenosis in an insulin dependent diabetes mellitus pa...
8083548 - Clinical evaluation of a herbal antidiabetic product.
17065668 - Long-term efficacy of metformin therapy in nonobese individuals with type 2 diabetes.
2444638 - Histochemical and biochemical investigation of adrenergic, cholinergic and peptidergic ...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical and investigative medicine. Médecine clinique et experimentale     Volume:  9     ISSN:  0147-958X     ISO Abbreviation:  Clin Invest Med     Publication Date:  1986  
Date Detail:
Created Date:  1986-05-05     Completed Date:  1986-05-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7804071     Medline TA:  Clin Invest Med     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  12-4     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Glucose / metabolism*
Clinical Trials as Topic
Diabetes Mellitus, Type 1 / drug therapy*
Diabetes Mellitus, Type 2 / drug therapy*
Fenfluramine / therapeutic use*
Hypoglycemic Agents*
Insulin / therapeutic use
Middle Aged
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Hypoglycemic Agents; 11061-68-0/Insulin; 458-24-2/Fenfluramine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Linear glomerular IgG fixation in renal allografts: incidence and significance in Alport's syndrome.
Next Document:  The contribution of lymphatic drainage to the clearance of inhaled 99mTc-DTPA from the lungs.