| Hypoglycemic and β-cells regenerative effects of Aegle marmelos (L.) Corr. bark extract in streptozotocin-induced diabetic rats. | |
| | |
MedLine Citation:
|
PMID: 22310238 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The aim of this study was to examine the antidiabetic potential of Aegle marmelos (L.) Corr. (Rutaceae) bark in a diabetic rat model. Dose dependent effects of methanol extract of Aegle marmelos bark (AM) (200 and 400mg/kg) on blood glucose, plasma insulin, glycated haemoglobin (HbA1c), total protein, hepatic glycogen, marker enzymes of hepatic function and carbohydrate metabolism were evaluated in (streptozotocin) STZ-induced diabetic rats by oral administration for 30days. Structural integrity of pancreatic islets was assessed by routine histology while, their functional status was assessed by immunolocalization for insulin. High-performance liquid chromatography (HPLC) study established that AM contained antihyperglycemic constituents, aegelin (1.27% w/w) and lupeol (0.29% w/w). AM at 200 and 400mg/kg showed significant reduction in blood glucose level by 19.14% and 47.32%, respectively in diabetic rats. AM treatment significantly increased insulin level, and produced similar effects on other biochemical parameters. Histological studies showed the regenerative effect of AM on the β-cells of diabetic rats. Immunohistochemical observations in the extract treated diabetic rats showed increased insulin-immunoreactive β-cells. These findings suggest that A. marmelos bark extract has the therapeutic potential in STZ-induced hyperglycemia; hence it can be used in the treatment of diabetes mellitus. |
| | |
Authors:
|
Gopalsamy Rajiv Gandhi; Savarimuthu Ignacimuthu; Michael Gabriel Paulraj |
Related Documents
:
|
17496368 - Animal models in type 2 diabetes research: an overview. 2792588 - Genetic studies of type 2 (non-insulin-dependent) diabetes mellitus: lack of associatio... 20002468 - Role of glucotoxicity and lipotoxicity in the pathophysiology of type 2 diabetes mellit... 19633998 - Comparison of atherosclerotic plaque burden and composition between diabetic and non di... 18525058 - Surgery for obesity in adults. 22013098 - Distinct changes in serum fibroblast growth factor 21 levels in different subtypes of d... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-30 |
Journal Detail:
|
Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: - ISSN: 1873-6351 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012. Published by Elsevier Ltd. |
Affiliation:
|
Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antitumor activities of quercetin and quercetin-5',8-disulfonate in human colon and breast cancer ce...
Next Document: Soil-transmitted helminthiasis: a critical but neglected factor influencing school participation of ...