Document Detail

Hypoglycemia induced by alpha-adrenergic stimulation during alkalosis.
MedLine Citation:
PMID:  188665     Owner:  NLM     Status:  MEDLINE    
Hypoglycemia developed during respiratory alkalosis in fasted rats. This hypoglycemia was markedly potentiated by the simultaneous injection of inhibitors of hepatic gluconeogenesis or a beta-adrenergic blocking agent; was not influenced by anti-insulin serum; was attenuated by hexamethonium; and was abolished by an alpha-adrenergic blocking agent. The rate of removal of injected glucose by peripheral tissues increased during alkalosis in insulin-deficient rats. The uptake of [14C]-glucose by the adipose tissue in vivo, which is stimulated by a very minute amount of insulin, was also stimulated during alkalosis whether or not the circulating insulin was neutralized with anti-insulin serum. It was concluded that, in alkalotic rats, blood glucose is rapidly utilized by peripheral tissues dependent on alpha-adrenergic stimulation, but without mediation of insulin and that this leads to development of hypoglycemia.
M Yajima; M Ui
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  41     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1977 Jan 
Date Detail:
Created Date:  1977-03-21     Completed Date:  1977-03-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  93-102     Citation Subset:  IM    
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MeSH Terms
Alkalosis, Respiratory / complications*,  metabolism,  physiopathology
Blood Glucose / metabolism*
Fatty Acids, Nonesterified / blood
Gluconeogenesis / drug effects
Glucose / metabolism
Hypoglycemia / blood,  etiology*
Insulin / blood,  pharmacology
Receptors, Adrenergic / physiology*
Receptors, Adrenergic, alpha / drug effects,  physiology*
Stimulation, Chemical
Time Factors
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Receptors, Adrenergic; 0/Receptors, Adrenergic, alpha; 11061-68-0/Insulin; 50-99-7/Glucose

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