| Hypoglycemia in type 1 diabetes mellitus. | |
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MedLine Citation:
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PMID: 20723825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Iatrogenic hypoglycemia, typically the result of the interplay of therapeutic hyperinsulinemia and compromised defenses resulting in hypoglycemia-associated autonomic failure (HAAF) in diabetes, is a problem for people with type 1 diabetes mellitus (T1DM). It causes recurrent morbidity is sometimes fatal, leads to recurrent hypoglycemia, and precludes euglycemia over a lifetime of T1DM. Risk factors include those that result in relative or absolute insulin excess and those indicative of HAAF in diabetes. Elimination of hypoglycemia from the lives of people with T1DM will likely be accomplished by new treatment methods that provide plasma glucose-regulated insulin replacement or secretion. |
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Authors:
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Philip E Cryer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Endocrinology and metabolism clinics of North America Volume: 39 ISSN: 1558-4410 ISO Abbreviation: Endocrinol. Metab. Clin. North Am. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-20 Completed Date: 2010-12-06 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 8800104 Medline TA: Endocrinol Metab Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 641-54 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Medicine, Washington University School of Medicine, Campus Box 8127, 660 South Euclid Avenue, St Louis, MO 63110, USA. pcryer@wustl.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Glucose
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analysis Diabetes Mellitus, Type 1 / blood, complications*, therapy Humans Hypoglycemia / diagnosis, epidemiology, etiology*, therapy Models, Biological Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR00036/RR/NCRR NIH HHS; P60 DK20579/DK/NIDDK NIH HHS; R37 DK027085-29/DK/NIDDK NIH HHS; R37 DK27085/DK/NIDDK NIH HHS; T32 DK07120/DK/NIDDK NIH HHS; UL1 RR24992/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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