Document Detail

Hypoglycemia as a driver of cardiovascular risk in diabetes.
MedLine Citation:
PMID:  23881546     Owner:  NLM     Status:  MEDLINE    
Severe hypoglycemia in patients with diabetes is associated with increased risk of adverse cardiovascular events and death. Recent large randomized clinical trials in individuals with type 2 diabetes have shown that intensive glycemic control may result in increased mortality, and hypoglycemia has been investigated as a possible cause. Acute hypoglycemia is a proarrhythmic, proinflammatory, and prothrombotic state, and several mechanisms have been proposed to explain how hypoglycemia might increase cardiovascular morbidity and mortality. However, data from large clinical trials do not provide strong evidence to establish hypoglycemia as a cause of increased mortality. Severe hypoglycemia is also a marker of frailty and a predictor of adverse outcomes in patients with diabetes. Individualized therapy should be the goal in patients with diabetes to avoid severe hypoglycemia and any related adverse outcomes.
Amir Moheet; Elizabeth R Seaquist
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current atherosclerosis reports     Volume:  15     ISSN:  1534-6242     ISO Abbreviation:  Curr Atheroscler Rep     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-07-24     Completed Date:  2014-04-02     Revised Date:  2014-09-02    
Medline Journal Info:
Nlm Unique ID:  100897685     Medline TA:  Curr Atheroscler Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  351     Citation Subset:  IM    
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MeSH Terms
Blood Glucose / metabolism*
Cardiovascular Diseases / etiology*,  mortality
Diabetes Mellitus, Type 2 / complications*,  drug therapy,  mortality
Hypoglycemia / complications*,  mortality,  prevention & control
Hypoglycemic Agents / therapeutic use
Risk Factors
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Hypoglycemic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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