Document Detail


Hypoglycemia is associated with increased risk for brain injury and adverse neurodevelopmental outcome in neonates at risk for encephalopathy.
MedLine Citation:
PMID:  22306045     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the contribution of hypoglycemia in the first 24 hours after birth to brain injury in term newborns at risk for neonatal encephalopathy.
STUDY DESIGN: A prospective cohort of 94 term neonates born between 1994 and 2010 with early postnatal brain magnetic resonance imaging studies were analyzed for regions of brain injury. Neurodevelopmental outcome was assessed at 1 year of age.
RESULTS: Hypoglycemia (glucose <46 mg/dL) in the first 24 hours after birth was detected in 16% of the cohort. Adjusting for potential confounders of early perinatal distress and need for resuscitation, neonatal hypoglycemia was associated with a 3.72-fold increased odds of corticospinal tract injury (P=.047). Hypoglycemia was also associated with 4.82-fold increased odds of 1-point worsened neuromotor score (P=.038) and a 15-point lower cognitive and language score on the Bayley Scales of Infant Development (P=.015).
CONCLUSION: Neonatal hypoglycemia is associated with additional risks in the setting of neonatal encephalopathy with increased corticospinal tract injury and adverse motor and cognitive outcomes.
Authors:
Emily W Y Tam; Laurel A Haeusslein; Sonia L Bonifacio; Hannah C Glass; Elizabeth E Rogers; Rita J Jeremy; A James Barkovich; Donna M Ferriero
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-02-04
Journal Detail:
Title:  The Journal of pediatrics     Volume:  161     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-25     Completed Date:  2012-09-10     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  88-93     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
Affiliation:
Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Brain Diseases / epidemiology,  etiology*
Child Development*
Cohort Studies
Female
Humans
Hypoglycemia / complications*
Infant, Newborn
Male
Nervous System / growth & development*
Prospective Studies
Risk Factors
Grant Support
ID/Acronym/Agency:
5R13 NS040925/NS/NINDS NIH HHS; K23 NS066137-03/NS/NINDS NIH HHS; NINDS 1K23NS066137/NS/NINDS NIH HHS; P50 NS035902/NS/NINDS NIH HHS; P50 NS035902-11A1/NS/NINDS NIH HHS; P50 NS35902/NS/NINDS NIH HHS; R01 NS046432/NS/NINDS NIH HHS; R01 NS046432-08/NS/NINDS NIH HHS; UL1 RR024131/RR/NCRR NIH HHS; UL1 RR024131/RR/NCRR NIH HHS; UL1 RR024131-04S3/RR/NCRR NIH HHS
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