Document Detail


Hypoglycaemia-induced changes in regional brain volume and memory function.
MedLine Citation:
PMID:  23330574     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Hypoglycaemic events can be a serious complication of insulin therapy in Type 1 diabetes mellitus. Severe hypoglycaemic exposure can lead to episodic memory impairments, including anterograde amnesia. However, relatively little is known regarding the long-term impact of severe hypoglycaemia on brain structure in Type 1 diabetes mellitus. The goals of the present study were to gain a greater understanding of the long-term effects of severe hypoglycaemia exposure on brain structure and the neural correlates of memory impairments in Type 1 diabetes mellitus.
CASE REPORT: Regional grey and white matter volume and total white matter lesion volume were quantified in an individual with long-standing hypoglycaemia-induced anterograde amnesia and compared with age- and gender-matched healthy controls. Our patient has significant reductions in grey matter volume in the hippocampus, thalamus and pallidum, and significant reductions in white matter volume in the splenium, isthmus of the cingulate and cerebellum. He also has a significantly larger total white matter lesion volume than controls.
CONCLUSION: This case study highlights the potential of hypoglycaemia for permanent deleterious effects on brain structure and memory function. Our results suggest that subcortical grey matter, periventricular white matter and posterior white matter may be most susceptible to injury from hypoglycaemia exposure, and that structural damage to the hippocampus and isthmus of the cingulate may play a central role in hypoglycaemia-induced memory impairments.
Authors:
B A Kirchhoff; H M Lugar; S E Smith; E J Meyer; D C Perantie; B C Kolody; J M Koller; A M Arbelaez; J S Shimony; T Hershey
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetic medicine : a journal of the British Diabetic Association     Volume:  30     ISSN:  1464-5491     ISO Abbreviation:  Diabet. Med.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-18     Completed Date:  2013-09-05     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  8500858     Medline TA:  Diabet Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  e151-6     Citation Subset:  IM    
Copyright Information:
© 2013 The Authors. Diabetic Medicine © 2013 Diabetes UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amnesia, Anterograde
Brain Diseases / pathology,  psychology*
Case-Control Studies
Diabetes Mellitus, Type 1 / drug therapy,  pathology,  psychology*
Humans
Hypoglycemia / pathology,  psychology*
Hypoglycemic Agents / adverse effects
Intelligence
Magnetic Resonance Imaging
Male
Neurologic Examination
Organ Size
Grant Support
ID/Acronym/Agency:
DK64832/DK/NIDDK NIH HHS; P30 DK056341/DK/NIDDK NIH HHS; R01 DK064832/DK/NIDDK NIH HHS; TL1 TR000449/TR/NCATS NIH HHS; UL1 RR024992/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Hypoglycemic Agents
Comments/Corrections

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