Document Detail

Hypofractionation for clinically localized prostate cancer.
MedLine Citation:
PMID:  23763885     Owner:  NLM     Status:  In-Data-Review    
This manuscript reviews the clinical evidence for hypofractionation in prostate cancer, focusing on data from prospective trials. For the purposes of this manuscript, we categorize hypofractionation as moderate (2.4-4 Gy per fraction) or extreme (6.5-10 Gy per fraction). Five randomized controlled trials have evaluated moderate hypofractionation in >1500 men, with most followed for >4-5 years. The results of these randomized trials are inconsistent. No randomized trials or other rigorous comparisons of extreme hypofractionation with conventional fractionation have been reported. Prospective single-arm studies of extreme hypofractionation appear favorable, but small sample sizes preclude precise estimates of efficacy and short follow-up prevents complication estimates beyond 3-5 years. Over the next several years, the results of 3 large noninferiority trials of moderate hypofractionation and 2 randomized trials of extreme hypofractionation should help clarify the role of hypofractionation in prostate cancer therapy.
Alvin R Cabrera; W Robert Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in radiation oncology     Volume:  23     ISSN:  1532-9461     ISO Abbreviation:  Semin Radiat Oncol     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9202882     Medline TA:  Semin Radiat Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  191-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Department of Radiation Oncology, Duke Cancer Institute, Durham, NC. Electronic address:
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