| Hypofractionated Conformal Radiotherapy (HCRT) for primary and metastatic lung cancers with small dimension : efficacy and toxicity. | |
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MedLine Citation:
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PMID: 19224144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: : To report on the clinical outcome of hypofractionated conformal radiotherapy (HCRT) for medically inoperable stage I non-small cell lung carcinoma (NSCLC) or limited pulmonary metastases </= 5 cm in diameter. PATIENTS AND METHODS: : From June 2003 to March 2007, 40 patients (42 lesions) underwent HCRT consisting of 40 Gy in five fractions over 2.5 weeks received by at least 95% of planning target volume. All patients underwent CT simulation and treatment under free shallow breathing. To evaluate target displacement under respiratory activity, two additional CT scans were performed with breath-holding during the expiratory and inspiratory phases. Of all patients enrolled, those with a follow-up > or = 4 months were considered suitable for analysis. Local response was evaluated with CT imaging 4 months after the end of HCRT and every 3 months thereafter. Local relapse-free survival (LRFS) and overall survival (OS) were calculated with the Kaplan-Meier method. RESULTS: : Local response to the treatment was complete response, partial response, no change, and progressive disease as seen in 29%, 43%, 14%, and 7% of tumors, respectively. LRFS at 1 year and 3 years was 76% and 63%, respectively. Lung toxicities > or = grade 2 were observed in 4/40 patients, but no grade 4. Pericardial effusion occurred in one patient. In stage I NSCLC patients (n = 15) with a median follow-up of 25 months, the 1-year LRFS and OS rates were 88% and 81%, respectively, and the 3-year rates 72% and 61%, respectively. CONCLUSION: : HCRT is an effective and low-toxic treatment for medically inoperable early-stage lung cancers and pulmonary metastases for all clinicians lacking the aid of a dedicated stereotactic system. |
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Authors:
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Maria Alessandra Mirri; Giorgio Arcangeli; Marcello Benassi; Annelisa d'Angelo; Valentina Pinzi; Mauro Caterino; Massimo Rinaldi; Anna Ceribelli; Lidia Strigari |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2009-02-18 |
Journal Detail:
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Title: Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al] Volume: 185 ISSN: 1439-099X ISO Abbreviation: Strahlenther Onkol Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-02-19 Completed Date: 2009-07-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8603469 Medline TA: Strahlenther Onkol Country: Germany |
Other Details:
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Languages: eng Pagination: 27-33 Citation Subset: IM |
Affiliation:
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S.C. Radioterapia Oncologica, Regina Elena National Cancer Institute, Rome, Italy. mamirri@inwind.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Dose Fractionation Dose-Response Relationship, Radiation Female Humans Lung Neoplasms / radiography, radiotherapy*, secondary* Male Middle Aged Radiotherapy Dosage Radiotherapy, Conformal / adverse effects, methods* Treatment Outcome |
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