Document Detail


Hypofibrinolysis is a risk factor for arterial thrombosis at young age.
MedLine Citation:
PMID:  19183334     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relationship between defective fibrinolysis and arterial thrombosis is uncertain. The evaluation of the plasma fibrinolytic potential might provide stronger evidence linking fibrinolysis to arterial thrombosis than the evaluation of the individual fibrinolytic factors. We determined the plasma fibrinolytic potential of 335 young survivors of a first arterial thrombosis, including coronary artery disease (n = 198), ischaemic stroke (n = 103) and peripheral artery disease (n = 34), enrolled in a population-based case-control study and of 330 healthy individuals. Patients had significantly higher clot lysis times (CLTs) than the controls. Odds ratios (ORs) were calculated as a measure of relative risk. The OR for arterial thrombosis was determined in these subjects who had a CLT above the 60th, 70th, 80th, 90th and 95th percentiles of the values found in the control subjects. We found a progressive increase in risk of arterial thrombosis in subjects with hypofibrinolysis (OR: 1.7, 2.0, 2.3, 2.3 and 2.9, respectively). Relative risk estimates obtained in the whole group were comparable those obtained in the event-subgroups. In conclusion, a low plasma fibrinolytic potential, found in 10% of the population, increases the relative risk of arterial thrombosis twofold. This points to an important contribution of hypofibrinolysis to the burden of arterial thrombosis.
Authors:
Ana H C Guimarães; Emile L E de Bruijne; Ton Lisman; Diederik W J Dippel; Jaap W Deckers; Don Poldermans; Dingeman C Rijken; Frank W G Leebeek
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-30
Journal Detail:
Title:  British journal of haematology     Volume:  145     ISSN:  1365-2141     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-18     Completed Date:  2009-06-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  115-20     Citation Subset:  IM    
Affiliation:
Department of Haematology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Body Mass Index
Brain Ischemia / blood,  physiopathology
Case-Control Studies
Coronary Artery Disease / blood,  physiopathology
Female
Fibrinolysis / drug effects,  physiology*
Humans
Male
Middle Aged
Odds Ratio
Peripheral Vascular Diseases / blood,  physiopathology
Risk
Thrombosis / blood*,  physiopathology
Tissue Plasminogen Activator / diagnostic use
Young Adult
Chemical
Reg. No./Substance:
EC 3.4.21.68/Tissue Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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