Document Detail


Hypodipsia-hypernatremia syndrome associated with holoprosencephaly in a child: a case report.
MedLine Citation:
PMID:  12405444     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a child with diabetes insipidus and hypodipsia associated with holoprosencephaly. A two-year-old girl with the history of several admittances to hospital during and after the newborn period with hypernatremic dehydration, acute renal failure and convulsions is presented. The patient had hypodipsia, hypernatremia, microcephaly, failure to thrive, and unilateral cleft lip and palate. Magnetic resonance imaging revealed lobar type holoprosencephaly. Increased plasma osmolality and decreased urinary osmolality were detected. Her urine ADH level was 10 ng/day. Plasma osmolality levels returned to normal after hydration and administration of a vasopressin analogue. These findings suggest that in children with hypernatremia-hypodipsia syndrome, the possibility of cerebral malformations should always be kept in mind.
Authors:
Aysun Karabay-Bayazit; Ozlem Hergüner; Sakir Altunbaşak; Aytül Noyan; Bilgin Yükel; Ali Anarat
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Turkish journal of pediatrics     Volume:  44     ISSN:  0041-4301     ISO Abbreviation:  Turk. J. Pediatr.     Publication Date:    2002 Jul-Sep
Date Detail:
Created Date:  2002-10-30     Completed Date:  2002-11-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417505     Medline TA:  Turk J Pediatr     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  263-6     Citation Subset:  IM    
Affiliation:
Department of Pediatric Nephrology, Cukurova University, Faculty of Medicine, Adana, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Child, Preschool
Dehydration / etiology*
Diabetes Insipidus / complications
Female
Holoprosencephaly / complications*
Humans
Hypernatremia / etiology*
Thirst*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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