| Hypocretin deficiency in narcoleptic humans is associated with abdominal obesity. | |
| | |
MedLine Citation:
|
PMID: 12972686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine the prevalence of obesity among patients with narcolepsy, to estimate associated long-term health risks on the basis of waist circumference, and to distinguish the impact of hypocretin deficiency from that of increased daytime sleepiness (i.e., reduced physical activity) on these anthropometric measures. RESEARCH METHODS AND PROCEDURES: A cross-sectional, case-control study was conducted. Patients with narcolepsy (n = 138) or idiopathic hypersomnia (IH) (n = 33) were included. Age-matched, healthy members of the Dutch population (Monitoring Project on Risk Factors for Chronic Diseases and Doetinchem Project; n = 10,526) were used as controls. BMI and waist circumference were determined. RESULTS: Obesity (BMI > or = 30 kg/m(2)) and overweight (BMI 25 to 30 kg/m(2)) occurred more often among narcolepsy patients [prevalence: 33% (narcoleptics) vs. 12.5% (controls) and 43% (narcoleptics) vs. 36% (controls), respectively; both p < 0.05]. Narcoleptics had a larger waist circumference (mean difference 5 +/- 1.4 cm, p < 0.001). The BMI of patients with IH was significantly lower than that of narcolepsy patients (25.6 +/- 3.6 vs. 28.5 +/- 5.4 kg/m(2); p = 0.004). DISCUSSION: Overweight and obesity occur frequently in patients with narcolepsy. Moreover, these patients have an increased waist circumference, indicating excess fat storage in abdominal depots. The fact that patients with IH had a lower BMI than narcoleptics supports the notion that excessive daytime sleepiness (i.e., inactivity) cannot account for excess body fat in narcoleptic patients. |
| | |
Authors:
|
Simon W Kok; Sebastiaan Overeem; Tommy L S Visscher; Gert Jan Lammers; Jaap C Seidell; Hanno Pijl; Arend E Meinders |
Related Documents
:
|
9640566 - Comparison of pain, motility, and preoperative sedation in cataract phacoemulsification... 7958156 - The prognostic value of magnetic resonance imaging for the management of breech delivery. 20608096 - Reversal of vecuronium with neostigmine: a comparison between male and female patients. 16905076 - Do race, gender, and source of payment impact on anesthetic technique for inguinal hern... 20569226 - Bilateral and recurrent optic neuritis in multiple sclerosis. 3958766 - Results of semen cryopreservation in young men with testicular carcinoma and lymphoma. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Obesity research Volume: 11 ISSN: 1071-7323 ISO Abbreviation: Obes. Res. Publication Date: 2003 Sep |
Date Detail:
|
Created Date: 2003-09-15 Completed Date: 2004-02-05 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9305691 Medline TA: Obes Res Country: United States |
Other Details:
|
Languages: eng Pagination: 1147-54 Citation Subset: IM |
Affiliation:
|
Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abdomen
/
anatomy & histology* Adult Aged Aged, 80 and over Body Constitution* Body Mass Index Carrier Proteins Case-Control Studies Cross-Sectional Studies Female Humans Hypersomnolence, Idiopathic / blood, complications* Intracellular Signaling Peptides and Proteins* Male Middle Aged Narcolepsy / blood, complications* Neuropeptides / deficiency* Obesity / blood, epidemiology*, etiology Prevalence |
| Chemical | |
Reg. No./Substance:
|
0/Carrier Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/orexins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: What's in a name? Patients' preferred terms for describing obesity.
Next Document: Serum sialic acid levels and selected mineral status in patients with type 2 diabetes mellitus.