Document Detail

Hypocretin deficiency in narcoleptic humans is associated with abdominal obesity.
MedLine Citation:
PMID:  12972686     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the prevalence of obesity among patients with narcolepsy, to estimate associated long-term health risks on the basis of waist circumference, and to distinguish the impact of hypocretin deficiency from that of increased daytime sleepiness (i.e., reduced physical activity) on these anthropometric measures. RESEARCH METHODS AND PROCEDURES: A cross-sectional, case-control study was conducted. Patients with narcolepsy (n = 138) or idiopathic hypersomnia (IH) (n = 33) were included. Age-matched, healthy members of the Dutch population (Monitoring Project on Risk Factors for Chronic Diseases and Doetinchem Project; n = 10,526) were used as controls. BMI and waist circumference were determined. RESULTS: Obesity (BMI > or = 30 kg/m(2)) and overweight (BMI 25 to 30 kg/m(2)) occurred more often among narcolepsy patients [prevalence: 33% (narcoleptics) vs. 12.5% (controls) and 43% (narcoleptics) vs. 36% (controls), respectively; both p < 0.05]. Narcoleptics had a larger waist circumference (mean difference 5 +/- 1.4 cm, p < 0.001). The BMI of patients with IH was significantly lower than that of narcolepsy patients (25.6 +/- 3.6 vs. 28.5 +/- 5.4 kg/m(2); p = 0.004). DISCUSSION: Overweight and obesity occur frequently in patients with narcolepsy. Moreover, these patients have an increased waist circumference, indicating excess fat storage in abdominal depots. The fact that patients with IH had a lower BMI than narcoleptics supports the notion that excessive daytime sleepiness (i.e., inactivity) cannot account for excess body fat in narcoleptic patients.
Simon W Kok; Sebastiaan Overeem; Tommy L S Visscher; Gert Jan Lammers; Jaap C Seidell; Hanno Pijl; Arend E Meinders
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obesity research     Volume:  11     ISSN:  1071-7323     ISO Abbreviation:  Obes. Res.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-15     Completed Date:  2004-02-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9305691     Medline TA:  Obes Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1147-54     Citation Subset:  IM    
Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.
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MeSH Terms
Abdomen / anatomy & histology*
Aged, 80 and over
Body Constitution*
Body Mass Index
Carrier Proteins
Case-Control Studies
Cross-Sectional Studies
Hypersomnolence, Idiopathic / blood,  complications*
Intracellular Signaling Peptides and Proteins*
Middle Aged
Narcolepsy / blood,  complications*
Neuropeptides / deficiency*
Obesity / blood,  epidemiology*,  etiology
Reg. No./Substance:
0/Carrier Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/orexins

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