| Hypocrellin derivative with improvements of red absorption and active oxygen species generation. | |
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MedLine Citation:
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PMID: 15006390 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A novel diamino-substituted hypocrellin derived from hypocrellin B (HB) was synthesized by a mild method. The red absorption of the resulting product was significantly enhanced relative to the parent hypocrellins and any other hypocrellin derivatives, and the active oxygen species generating abilities were enhanced distinctly, which will remarkably improve its photodynamic therapy effectiveness. |
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Authors:
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Shangjie Xu; Shen Chen; Manhua Zhang; Tao Shen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 14 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-09 Completed Date: 2004-10-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 1499-501 Citation Subset: IM |
Affiliation:
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Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Dihematoporphyrin Ether
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analysis,
chemistry Electron Spin Resonance Spectroscopy Nuclear Magnetic Resonance, Biomolecular / methods* Perylene / analogs & derivatives*, analysis, chemistry* Photosensitizing Agents / chemistry* Quinones / analysis, chemistry* Reactive Oxygen Species / chemistry*, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Photosensitizing Agents; 0/Quinones; 0/Reactive Oxygen Species; 198-55-0/Perylene; 77029-83-5/hypocrellin A; 97067-70-4/Dihematoporphyrin Ether |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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