Document Detail


Hypocrellin derivative with improvements of red absorption and active oxygen species generation.
MedLine Citation:
PMID:  15006390     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel diamino-substituted hypocrellin derived from hypocrellin B (HB) was synthesized by a mild method. The red absorption of the resulting product was significantly enhanced relative to the parent hypocrellins and any other hypocrellin derivatives, and the active oxygen species generating abilities were enhanced distinctly, which will remarkably improve its photodynamic therapy effectiveness.
Authors:
Shangjie Xu; Shen Chen; Manhua Zhang; Tao Shen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  14     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-09     Completed Date:  2004-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  1499-501     Citation Subset:  IM    
Affiliation:
Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080, China.
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MeSH Terms
Descriptor/Qualifier:
Dihematoporphyrin Ether / analysis,  chemistry
Electron Spin Resonance Spectroscopy
Nuclear Magnetic Resonance, Biomolecular / methods*
Perylene / analogs & derivatives*,  analysis,  chemistry*
Photosensitizing Agents / chemistry*
Quinones / analysis,  chemistry*
Reactive Oxygen Species / chemistry*,  metabolism*
Chemical
Reg. No./Substance:
0/Photosensitizing Agents; 0/Quinones; 0/Reactive Oxygen Species; 198-55-0/Perylene; 77029-83-5/hypocrellin A; 97067-70-4/Dihematoporphyrin Ether

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