| Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet. | |
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MedLine Citation:
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PMID: 20607063 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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There is an increasing interest in curcumin (Curcuma longa L.) as a cardiovascular disease (CVD) protective agent via decreased blood total cholesterol and low-density lipoprotein-cholesterol (LDL-cholesterol) level. The aim of this study was to investigate further the potential mechanism in the hypocholesterolemic effect of curcumin by measuring cholesterol 7a-hydroxylase (CYP7A1), a rate limiting enzyme in the biosynthesis of bile acid from cholesterol, at the mRNA level. Male Sprague-Dawley rats were fed a 45% high fat diet or same diet supplemented with curcumin (0.1% wt/wt) for 8 weeks. The curcumin diet significantly decreased serum triglyceride (TG) by 27%, total cholesterol (TC) by 33.8%, and LDL-cholesterol by 56%, respectively as compared to control group. The curcumin-supplemented diet also significantly lowered the atherogenic index (AI) by 48% as compared to control group. Hepatic TG level was significantly reduced by 41% in rats fed with curcumin-supplemented diet in comparison with control group (P < 0.05). Conversely, the curcumin diet significantly increased fecal TG and TC. The curcumin diet up-regulated hepatic CYP7A1 mRNA level by 2.16-fold, compared to control group p (P < 0.05). These findings suggested that the increases in the CYP7A1 gene expression may partially account for the hypocholesterolemic effect of curcumin. |
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Authors:
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Minji Kim; Yangha Kim |
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Publication Detail:
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Type: Journal Article Date: 2010-06-28 |
Journal Detail:
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Title: Nutrition research and practice Volume: 4 ISSN: 2005-6168 ISO Abbreviation: Nutr Res Pract Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101311052 Medline TA: Nutr Res Pract Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 191-5 Citation Subset: - |
Affiliation:
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Department of Nutritional Science and Food Management, Ewha Womans University, 11-1 Daehyn-dong, Seodaemun-gu, Seoul 120-750, Korea. |
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