| Hypocholesterolemic and antiatherosclerotic effect of artemisia aucheri in hypercholesterolemic rabbits. | |
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MedLine Citation:
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PMID: 20566447 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atherosclerosis which results from gradual deposition of lipids in arteries is a leading cause of mortality worldwide. Diet is one of the most important factors underlying atherosclerosis. High-cholesterol diets enhance atherosclerosis and vegetarian diets are known to slow down the process. Artemisia aucheri is an herb of the Composite family. Many species of Artemisia have proven hypolipidemic and antioxidant properties. This study determine the effects of Artemisia aucheri on lipoproteins and atherosclerosis in hypercholesterolemic rabbits. Fifteen male rabbits were randomly divided into three groups. Normal diet group, high-cholesterol diet group (1% cholesterol) and Artemisia aucheri group (1% cholesterol diet supplemented with 100 mg/kg body weight the Artemisi aucheri every other day). Biochemical factors were measured at the start, end of the first and second months of the study. At the end of the study, the aorta were removed for assessment of atherosclerotic plaques. The results indicate that Artemisia aucheri significantly reduced the level of total cholesterol, LDL cholesterol and triglycerids and increased HDL cholesterol. The degree of atherosclerotic thickness was significantly reduced in the treated group. Therefore, Artemisia aucheri is one of the useful herbal medicine for preventation of atherosclerosis and more studies in this regard is recommended. |
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Authors:
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N Jafari Dinani; Asgary Asgary; H Madani; Gh Naderi; P Mahzoni |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pakistan journal of pharmaceutical sciences Volume: 23 ISSN: 1011-601X ISO Abbreviation: Pak J Pharm Sci Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-22 Completed Date: 2010-08-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9426356 Medline TA: Pak J Pharm Sci Country: Pakistan |
Other Details:
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Languages: eng Pagination: 321-5 Citation Subset: IM |
Affiliation:
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Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticholesteremic Agents / therapeutic use* Artemisia* Atherosclerosis / drug therapy* Cholesterol / blood Hypercholesterolemia / drug therapy* Male Phytotherapy* Rabbits Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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