| Hypocholesterolemic activity of grape seed proanthocyanidin is mediated by enhancement of bile acid excretion and up-regulation of CYP7A1. | |
| | |
MedLine Citation:
|
PMID: 20092993 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Interest in grape seed proanthocyanidin (GSP) as a cholesterol-lowering nutraceutical is growing. This study was to investigate the effect of GSP on blood cholesterol level and gene expression of cholesterol-regulating enzymes in Golden Syrian hamsters maintained on a 0.1% cholesterol diet. Results affirmed supplementation of 0.5% or 1.0% GSP could decrease plasma total cholesterol and triacylglycerol level. Western blot and real-time polymerase chain reaction analyses demonstrated GSP did not affect sterol regulatory element binding protein-2 and low-density lipoprotein receptor; however, it increased mRNA 3-hydroxy-3-methylglutaryl coenzyme A reductase. GSP had no effect on the protein mass of liver X receptor alpha (LXRα) but it decreased mRNA LXRα. Most importantly, GSP increased not only the protein level of cholesterol-7α-hydroxylase (CYP7A1) but also mRNA CYP7A1. It was concluded that the hypocholesterolemic activity of GSP was most likely mediated by enhancement of bile acid excretion and up-regulation of CYP7A1. |
| | |
Authors:
|
Rui Jiao; Zesheng Zhang; Hongjian Yu; Yu Huang; Zhen-Yu Chen |
Related Documents
:
|
15730433 - Possible anti-atherogenic effect of kolaviron (a garcinia kola seed extract) in hyperch... 7772823 - Effects of isorhamnetin, rhamnetin, and quercetin on the concentrations of cholesterol ... 918353 - Effect of dietary ingestion of oxalic acid on growth and reproduction in male and femal... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-25 |
Journal Detail:
|
Title: The Journal of nutritional biochemistry Volume: 21 ISSN: 1873-4847 ISO Abbreviation: J. Nutr. Biochem. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-10-25 Completed Date: 2011-01-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9010081 Medline TA: J Nutr Biochem Country: United States |
Other Details:
|
Languages: eng Pagination: 1134-9 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Food and Nutritional Sciences Programme, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bile Acids and Salts / genetics, metabolism* Cholesterol / blood*, metabolism Cholesterol 7-alpha-Hydroxylase / genetics, metabolism* Cricetinae Grape Seed Extract / pharmacology* Male Mesocricetus Orphan Nuclear Receptors / metabolism Proanthocyanidins / pharmacology* Receptors, LDL / metabolism Sterol Regulatory Element Binding Protein 2 / genetics, metabolism Up-Regulation |
| Chemical | |
Reg. No./Substance:
|
0/Bile Acids and Salts; 0/Grape Seed Extract; 0/Grape Seed Proanthocyanidins; 0/Orphan Nuclear Receptors; 0/Proanthocyanidins; 0/Receptors, LDL; 0/Sterol Regulatory Element Binding Protein 2; 0/liver X receptor; 57-88-5/Cholesterol; EC 1.14.13.17/Cholesterol 7-alpha-Hydroxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pulmonary hypertension in lung diseases: Survey of beliefs and practice patterns.
Next Document: Abscisic acid ameliorates atherosclerosis by suppressing macrophage and CD4+ T cell recruitment into...