| Hypocholesterolemic action of pre-germinated brown rice in hepatoma-bearing rats. | |
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MedLine Citation:
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PMID: 16464476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of pre-germinated brown rice (PGBR) on cholesterol metabolism was studied in Donryu rats subcutaneously implanted with the ascites hepatoma cell line AH109A and compared with that of white rice (WR). The effect of brown rice (BR), the source of PGBR, was also studied. Hepatoma-bearing rats fed a WR diet exhibited hypercholesterolemia compared with normal rats fed the same diet. Feeding hepatoma-bearing rats a PGBR or BR diet suppressed hepatoma-induced hypercholesterolemia, and enhanced fecal bile acid excretion and the activity of cholesterol 7alpha-hydroxylase, the rate-limiting enzyme of bile acid biosynthesis, in the microsomal fraction of the liver without affecting cholesterol synthesis in the host liver of hepatoma-bearing rats. These results suggest that PGBR as well as BR suppresses hypercholesterolemia induced by hepatoma growth by up-regulating cholesterol catabolism. |
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Authors:
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Daiki Miura; Yukihiko Ito; Aya Mizukuchi; Mitsuo Kise; Hiromichi Aoto; Kazumi Yagasaki |
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Publication Detail:
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Type: Journal Article Date: 2006-02-07 |
Journal Detail:
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Title: Life sciences Volume: 79 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-01 Completed Date: 2006-08-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: England |
Other Details:
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Languages: eng Pagination: 259-64 Citation Subset: IM |
Affiliation:
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Department of Applied Biological Science, Tokyo Noko University, Fuchu, Tokyo 183-8509, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile Acids and Salts / analysis, metabolism Carcinoma, Hepatocellular / complications, metabolism* Cholesterol / metabolism* Cholesterol 7-alpha-Hydroxylase / analysis, metabolism Feces / chemistry Germination Hypercholesterolemia / diet therapy*, enzymology, etiology Liver Neoplasms, Experimental / complications, metabolism* Neoplasm Transplantation Oryza sativa* / growth & development Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 57-88-5/Cholesterol; EC 1.14.13.17/Cholesterol 7-alpha-Hydroxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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