Document Detail

Hypocapnia and hypercapnia in respiratory management of newborn infants.
MedLine Citation:
PMID:  11570152     Owner:  NLM     Status:  MEDLINE    
Recent experimental and clinical data demonstrate that both hypocapnia and hypercapnia during the neonatal period may result in beneficial or adverse consequences. Multiple retrospective studies report a strong association between PaCO2 levels less than 25 to 30 mm Hg and an increased incidence of cystic PVL and CP in preterm infants. Prolonged exposure to PaCO2 values less than 25 to 30 mm Hg is also associated with hearing loss in term and near-term infants. A low tidal volume strategy combined with permissive hypercapnia is potentially a strategy that could prevent lung injury. Clearly, more randomized, controlled trials are needed before this latter strategy or that of permissive hypercapnia can be recommended routinely for preterm, near-term, or term gestation infants with respiratory disorders.
N Ambalavanan; W A Carlo
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  28     ISSN:  0095-5108     ISO Abbreviation:  Clin Perinatol     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-25     Completed Date:  2002-01-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  517-31     Citation Subset:  IM    
Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
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MeSH Terms
Carbon Dioxide / blood*
Hypercapnia / complications,  etiology*,  physiopathology*
Hypocapnia / complications,  etiology*,  physiopathology*
Infant, Newborn / physiology*
Persistent Fetal Circulation Syndrome / therapy
Pulmonary Gas Exchange
Respiration, Artificial / adverse effects,  methods*
Respiratory Distress Syndrome, Newborn / therapy
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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