| Hypocapnia enhances the pressor effect of phenylephrine during isoflurane anesthesia in monkeys. | |
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MedLine Citation:
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PMID: 20118791 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phenylephrine was administered to increase arterial blood pressure in 6 monkeys anesthetized with isoflurane during both normocapnia (arterial partial pressure of CO2 35 to 44 mm Hg) and hypocapnia (arterial partial pressure of CO2 23 to 29 mm Hg). The doses of phenylephrine required to increase mean blood pressure to 33% and 66% above control pressure during hypocapnia [1.7+/-0.9 and 3.1+/-1.7 microg/kg/min (mean+/-SD), respectively] were significantly less than the doses required to achieve the same changes in blood pressure during normocapnia (2.4+/-0.9 and 4.9+/-2.4 microg/kg/min, respectively, P<0.05). In patients with intracranial pathology, for whom hypocapnia is frequently induced, phenylephrine dosage may need to be appropriately reduced. |
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Authors:
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Arthur E Schwartz; David C Adams |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neurosurgical anesthesiology Volume: 22 ISSN: 1537-1921 ISO Abbreviation: J Neurosurg Anesthesiol Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-23 Completed Date: 2010-06-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8910749 Medline TA: J Neurosurg Anesthesiol Country: United States |
Other Details:
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Languages: eng Pagination: 155-7 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Mount Sinai School of Medicine, New York, NY 10029, USA. arthur.schwartz@mountsinai.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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pharmacology* Anesthesia* Anesthetics, Inhalation* Animals Blood Pressure / drug effects* Carbon Dioxide / blood Female Heart Rate / drug effects Hypocapnia / physiopathology* Isoflurane* Macaca fascicularis Male Phenylephrine / pharmacology* Respiration, Artificial Vasoconstrictor Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Anesthetics, Inhalation; 0/Vasoconstrictor Agents; 124-38-9/Carbon Dioxide; 26675-46-7/Isoflurane; 59-42-7/Phenylephrine |
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