Document Detail

Hypocapnia enhances the pressor effect of phenylephrine during isoflurane anesthesia in monkeys.
MedLine Citation:
PMID:  20118791     Owner:  NLM     Status:  MEDLINE    
Phenylephrine was administered to increase arterial blood pressure in 6 monkeys anesthetized with isoflurane during both normocapnia (arterial partial pressure of CO2 35 to 44 mm Hg) and hypocapnia (arterial partial pressure of CO2 23 to 29 mm Hg). The doses of phenylephrine required to increase mean blood pressure to 33% and 66% above control pressure during hypocapnia [1.7+/-0.9 and 3.1+/-1.7 microg/kg/min (mean+/-SD), respectively] were significantly less than the doses required to achieve the same changes in blood pressure during normocapnia (2.4+/-0.9 and 4.9+/-2.4 microg/kg/min, respectively, P<0.05). In patients with intracranial pathology, for whom hypocapnia is frequently induced, phenylephrine dosage may need to be appropriately reduced.
Arthur E Schwartz; David C Adams
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgical anesthesiology     Volume:  22     ISSN:  1537-1921     ISO Abbreviation:  J Neurosurg Anesthesiol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-23     Completed Date:  2010-06-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910749     Medline TA:  J Neurosurg Anesthesiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  155-7     Citation Subset:  IM    
Department of Anesthesiology, Mount Sinai School of Medicine, New York, NY 10029, USA.
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology*
Anesthetics, Inhalation*
Blood Pressure / drug effects*
Carbon Dioxide / blood
Heart Rate / drug effects
Hypocapnia / physiopathology*
Macaca fascicularis
Phenylephrine / pharmacology*
Respiration, Artificial
Vasoconstrictor Agents / pharmacology*
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Anesthetics, Inhalation; 0/Vasoconstrictor Agents; 124-38-9/Carbon Dioxide; 26675-46-7/Isoflurane; 59-42-7/Phenylephrine

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