Document Detail

Hypocaloric diet and regular moderate aerobic exercise is an effective strategy to reduce anthropometric parameters and oxidative stress in obese patients.
MedLine Citation:
PMID:  22433613     Owner:  NLM     Status:  In-Data-Review    
Background: Studies show that diet and exercise are important in the treatment of obesity. The aim of this study was to determine whether additional regular moderate aerobic exercise during a treatment with hypocaloric diet has a beneficial effect on oxidative stress and molecular damage in the obese patient. Methods: Oxidative stress of 16 normal-weight (NW) and 32 obese 1 (O1) subjects (BMI 30-34.9 kg/m(2)) were established by biomarkers of oxidative stress in plasma. Recombinant human insulin was incubated with blood from NW or O1 subjects, and the molecular damage to the hormone was analyzed. Two groups of treatment, hypocaloric diet (HD) and hypocaloric diet plus regular moderate aerobic exercise (HDMAE), were formed, and their effects in obese subjects were analyzed. Results: The data showed the presence of oxidative stress in O1 subjects. Molecular damage and polymerization of insulin was observed more frequently in the blood from O1 subjects. The treatment of O1 subjects with HD decreased the anthropometric parameters as well as oxidative stress and molecular damage, which was more effectively prevented by the treatment with HDMAE. Conclusion: HD and HDMAE treatments decreased anthropometric parameters, oxidative stress, and molecular damage in O1 subjects. Copyright © 2012 S. Karger GmbH, Freiburg.
Liliana Gutierrez-Lopez; Jose Ruben Garcia-Sanchez; Maria de Jesus Rincon-Viquez; Eleazar Lara-Padilla; Martha P Sierra-Vargas; Ivonne M Olivares-Corichi
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Publication Detail:
Type:  Journal Article     Date:  2012-03-02
Journal Detail:
Title:  Obesity facts     Volume:  5     ISSN:  1662-4033     ISO Abbreviation:  Obes Facts     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101469429     Medline TA:  Obes Facts     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  12-22     Citation Subset:  IM    
Department of Sport and Informatics, Pablo de Olavide University, Sevilla, Spain.
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