Document Detail


Hypocalcemic rickets and dilated cardiomyopathy: case reports and review of literature.
MedLine Citation:
PMID:  19387720     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Internationally, there have been isolated case reports published of children presenting with dilated cardiomyopathy (DCM) in the setting of undiagnosed rickets. Although there has been an increased prevalence of rickets in the United States, there has been only one documented case of associated DCM. At our institution, a hospital database search was conducted from year 1997 to year 2007 to identify patients with confirmed vitamin D deficiency in addition to DCM. Through this search, four exclusively breast-fed African American infants were identified. These infants presented with congestive heart failure secondary to DCM and, at their admission, were found to have laboratory evidence consistent with hypocalcemic rickets. These patients responded dramatically to treatment with vitamin D and calcium, and cardiac function returned to normal within months. Early recognition of vitamin D deficiency was an important factor in these patients' clinical course. These case reviews present a rare, serious complication of vitamin D-deficient rickets and support evidence for prevention of this nutritional deficiency with vitamin D supplementation in exclusively breast-fed infants.
Authors:
Jennifer Brown; Susan Nunez; Melissa Russell; Christopher Spurney
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-04-23
Journal Detail:
Title:  Pediatric cardiology     Volume:  30     ISSN:  1432-1971     ISO Abbreviation:  Pediatr Cardiol     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-27     Completed Date:  2009-11-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  818-23     Citation Subset:  IM    
Affiliation:
Division of Pediatrics, Children's National Medical Center, 111 Michigan Avenue N.W, Washington, DC 20010, USA.
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MeSH Terms
Descriptor/Qualifier:
Calcium / blood*
Cardiomyopathy, Dilated / diagnosis,  etiology*
Echocardiography, Doppler, Color
Electrocardiography
Female
Follow-Up Studies
Humans
Hypocalcemia / blood,  complications*,  diagnosis
Infant
Male
Rickets
Chemical
Reg. No./Substance:
7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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