Document Detail

Hypocalcemia after therapeutic use of magnesium sulfate.
MedLine Citation:
PMID:  1275625     Owner:  NLM     Status:  MEDLINE    
It is now recognized that magnesium plays an important role in calcium homeostasis. Although the effects of hypomagnesemia have been frequently reported, little has been written to suggest a clinically important role for hypermagnesemia. A case is reported in which severe hypocalcemia, with a low plasma parathyroid hormone (PTH) concentration, resulted from the therapeutic use of magnesium sulfate for toxemia of pregnancy. Following recovery, the parathyroid glands were shown to respond normally to a phosphate load. It is suggested that the hypermagnesemia directly suppressed PTH secretion, resulting in symptomatic hypocalcemia.
E Eisenbud; C C LoBue
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  136     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  688-91     Citation Subset:  AIM; IM    
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MeSH Terms
Calcium / blood,  therapeutic use
Hypocalcemia / chemically induced*,  physiopathology
Magnesium Sulfate / adverse effects*,  therapeutic use
Parathyroid Glands / physiopathology
Parathyroid Hormone / blood
Potassium / administration & dosage
Pre-Eclampsia / drug therapy*
Reg. No./Substance:
0/Parathyroid Hormone; 7440-09-7/Potassium; 7440-70-2/Calcium; 7487-88-9/Magnesium Sulfate

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