Document Detail

Hypobaric intermittent hypoxia attenuates hypoxia-induced depressor response.
MedLine Citation:
PMID:  22848558     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hypobaric intermittent hypoxia (HIH) produces many favorable effects in the cardiovascular system such as anti-hypertensive effect. In this study, we showed that HIH significantly attenuated a depressor response induced by acute hypoxia.
METHODOLOGY/PRINCIPAL FINDINGS: Sprague-Dawley rats received HIH in a hypobaric chamber simulating an altitude of 5000 m. The artery blood pressure (ABP), heart rate (HR) and renal sympathetic nerve activity (RSNA) were recorded in anesthetized control rats and rats received HIH. The baseline ABP, HR and RSNA were not different between HIH and control rats. Acute hypoxia-induced decrease in ABP was significantly attenuated in HIH rat compared with control rats. However, acute hypoxia-induced increases in HR and RSNA were greater in HIH rat than in control rats. After removal of bilateral ascending depressor nerves, acute hypoxia-induced depressor and sympathoexcitatory responses were comparable in control and HIH rats. Furthermore, acute hypoxia-induced depressor and sympathoexcitatory responses did not differ between control and HIH groups after blocking ATP-dependent K(+) channels by glibenclamide. The baroreflex function evaluated by intravenous injection of phenylephrine and sodium nitroprusside was markedly augmented in HIH rats compared with control rats. The pressor and sympathoexcitatory responses evoked by intravenous injection of cyanide potassium were also significantly greater in HIH rats than in control rats.
CONCLUSIONS/SIGNIFICANCE: Our findings suggest that HIH suppresses acute hypoxia-induced depressor response through enhancement of baroreflex and chemoreflex function, which involves activation of ATP-dependent K(+) channels. This study provides new information and underlying mechanism on the beneficiary effect of HIH on maintaining cardiovascular homeostasis.
Fang Cui; Lu Gao; Fang Yuan; Ze-Fei Dong; Zhao-Nian Zhou; David D Kline; Yi Zhang; De-Pei Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-27
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-31     Completed Date:  2013-04-09     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e41656     Citation Subset:  IM    
Department of Physiology, Hebei Medical University, Shijiazhuang, China.
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MeSH Terms
Anoxia / metabolism,  physiopathology*
Baroreflex / drug effects
Blood Pressure / drug effects
Environment, Controlled*
Glyburide / pharmacology
Heart Rate / drug effects
KATP Channels / metabolism
Kidney / innervation
NG-Nitroarginine Methyl Ester / pharmacology
Rats, Sprague-Dawley
Sympathetic Nervous System / drug effects,  metabolism,  physiopathology*
Time Factors
Reg. No./Substance:
0/KATP Channels; 10238-21-8/Glyburide; 50903-99-6/NG-Nitroarginine Methyl Ester
Erratum In:
PLoS One. 2013;8(4). doi:10.1371/annotation/1b9eb18d-b23f-4a5c-8357-e517e209e821

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