Document Detail

Hypoallergenicity: a principle for the treatment of food allergy.
MedLine Citation:
PMID:  17245089     Owner:  NLM     Status:  MEDLINE    
Food allergy is a common disease with the treatment of choice being complete avoidance of the incriminated food. In cow's milk allergy a hypoallergenic milk substitute is necessary during infancy and childhood. Hypoallergenic formulas are produced through enzymatic hydrolysis of different sources such as bovine casein or whey followed by further processing such as heat treatment and/or ultrafiltration. According to the degree of protein hydrolysis the resulting products have been classified into 'extensively' or 'partially' hydrolyzed. Reduction of allergenicity should be assessed in vitro and in vivo. Hypoallergenic formulas might also be based on amino acid mixtures. These elementary diets can be considered as nonallergenic. Several novel therapies are currently being explored in food allergy. One of the most promising approaches is the immunotherapy with mutated proteins. For this approach, alteration of the IgEbinding sites through single amino acid substitution is performed resulting in reduced to complete loss of IgE binding. For the major peanut allergens such mutations were introduced into the cDNA sequences and successfully expressed as hypoallergenic recombinant proteins. In peanut-sensitized mice, the use of these modified proteins co-administered with adjuvant such as heat-killed Escherichia coli showed promising results for future therapeutic approaches.
Kirsten Beyer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nestlé Nutrition workshop series. Paediatric programme     Volume:  59     ISSN:  1661-6677     ISO Abbreviation:  -     Publication Date:  2007  
Date Detail:
Created Date:  2007-01-24     Completed Date:  2007-04-02     Revised Date:  2007-09-07    
Medline Journal Info:
Nlm Unique ID:  101244056     Medline TA:  Nestle Nutr Workshop Ser Pediatr Program     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  37-43; discussion 43-7     Citation Subset:  IM    
Department of Pediatric Pneumology and Immunology, Charité Universitätsmedizin, University Children's Hospital, Augustenburgerplatz 1, DE-13353 Berlin, Germany.
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MeSH Terms
Allergens / immunology*
Child, Preschool
Food Hypersensitivity / diet therapy,  immunology*
Immune Tolerance
Immunoglobulin E / immunology
Infant Formula / chemistry
Infant, Newborn
Milk Hypersensitivity / diet therapy,  immunology*
Milk Proteins / immunology
Peanut Hypersensitivity / diet therapy,  immunology
Protein Hydrolysates / immunology,  therapeutic use*
Reg. No./Substance:
0/Allergens; 0/Milk Proteins; 0/Protein Hydrolysates; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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