| Hypoallergenicity and effects on growth and tolerance of a new amino acid-based formula with docosahexaenoic acid and arachidonic acid. | |
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MedLine Citation:
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PMID: 18534230 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: In study 1, to compare the effect on growth in healthy infants of a new amino acid-based formula (AAF) and a control extensively hydrolyzed formula (EHF), with both docosahexaenoic acid (DHA) and arachidonic acid (ARA) at levels similar to those in human milk worldwide. In study 2, to evaluate the hypoallergenicity of this new AAF in infants and children with confirmed cow's milk allergy (CMA). STUDY DESIGN: In study 1, a total of 165 healthy, full-term, formula-fed infants randomly received the new AAF or control formula. Anthropometric measurements, tolerance, and adverse events were recorded throughout the study. Plasma amino acid profiles were evaluated in a subset of the infants. In study 2, the hypoallergenicity of the new AAF was evaluated in 32 infants and children using a double-blind, placebo-controlled food challenge; an open challenge; and a 7-day feeding. RESULTS: In study 1, overall growth, tolerance, and safety outcomes were similar in both groups. In study 2, 29 of the 32 subjects completed both challenges; no allergic reaction was seen in any of the 32 subjects. CONCLUSIONS: The new AAF with DHA and ARA at levels similar to those in human milk worldwide is hypoallergenic. It also is safe and supports growth in healthy, term infants. |
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Authors:
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Wesley Burks; Stacie M Jones; Carol Lynn Berseth; Cheryl Harris; Hugh A Sampson; Deolinda M F Scalabrin |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2008-04-09 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 153 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-21 Completed Date: 2008-08-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 266-71 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Duke University Medical Center, Durham, NC, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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administration & dosage* Animals Arachidonic Acid / administration & dosage* Child Child, Preschool Dietary Supplements Docosahexaenoic Acids / administration & dosage* Double-Blind Method Female Growth / drug effects Humans Infant Infant Food / adverse effects Infant Formula / administration & dosage* Infant, Newborn Male Milk / adverse effects Milk Hypersensitivity / diet therapy*, etiology Prospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid |
| Comments/Corrections | |
Comment In:
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J Pediatr. 2008 Aug;153(2):A2
[PMID:
18639715
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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