Document Detail

Hypoalbuminemia and not hyperhomocysteinemia as a risk factor for dementia in hemodialysis patients.
MedLine Citation:
PMID:  18558299     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The most common causes of morbidity and mortality in uremic patients are cardiovascular disease and central nervous system dysfunction. However, the exact causes of dementia in uremic patients remain unclear. This study attempted to determine which risk factors are associated with dementia in hemodialysis patients. METHODS: In total, 147 chronic uremic patients receiving regular hemodialysis treatment were recruited. Data for risk factors regarding cardiovascular disease and dementia, such as hypertension, diabetes mellitus, smoking, age, illiteracy, serum levels of albumin, cholesterol, triglycerides, and homocysteine, and liver function, were recorded. The Mini-Mental Status examination was used to assess mental function, and the Hachinski ischemic scale was applied to differentiate among dementia types. The diagnosis of dementia was based on criteria from the Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition. RESULTS: Twenty-six patients were diagnosed as manifesting dementia. Of all patients with dementia, 21 had a Hachinski score of 0 to 4, and 5 had a score of 7 to 10. In a multiple logistic regression analysis, low serum albumin and illiteracy were significantly associated with dementia. However, no difference existed between the two groups in terms of homocysteine levels. CONCLUSIONS: This study demonstrated that uremic patients were prone to nonvascular dementia. We conclude that hypoalbuminemia and not hyperhomocysteinemia is a risk factor for dementia in hemodialysis patients.
Ying-Chih Huang; Ya-Wen Kuo; Tsong-Hai Lee; Meng Lee; Ming-Chang Hsiao; Chia-Lian Wang; Jiann-Der Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation     Volume:  18     ISSN:  1532-8503     ISO Abbreviation:  J Ren Nutr     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-18     Completed Date:  2008-09-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112938     Medline TA:  J Ren Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  347-54     Citation Subset:  IM    
Department of Neurology, Chang Gung Memorial Hospital, Chang Gung Institute of Technology, Chiayi, Taiwan.
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MeSH Terms
Age Factors
Aged, 80 and over
Dementia / epidemiology,  etiology*
Hyperhomocysteinemia / complications*,  psychology
Hypoalbuminemia / complications*,  psychology
Logistic Models
Middle Aged
Renal Dialysis*
Risk Factors
Uremia / complications,  psychology

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