| Hypoadiponectinemia is associated with prehypertension in obese individuals of multiethnic origin. | |
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MedLine Citation:
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PMID: 20552610 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Considering that prehypertension is associated with an increase in cardiovascular risk, hypoadiponectinemia seems to be a predictor of hypertension. HYPOTHESIS: This study investigated whether adiponectin plasma levels are affected in Brazilian obese prehypertensives compared with those in normotensives and hypertensives. METHODS: The study involved 96 multiethnic obese subjects (mean age = 42.8-11.9 years; BMI = 35.7-7.3 kg/m(2)). Fasting plasma adiponectin and serum insulin were determined by radioimmunoassay. Insulin resistance was estimated by HOMA-IR. Blood pressure was recorded using a calibrated automated sphygmomanometer. RESULTS: Adiponectin concentrations were significantly lower in prehypertensives compared with those in normotensives, but hypertensives exhibited the lowest adiponectin concentrations of all. Regarding the values of HOMA-IR, both prehypertensives and hypertensives were significantly more insulin resistant when compared with normotensives. When normotensives and prehypertensives were classified according to the 50th percentile of adiponectin (< or = vs > 6.5 mg/ml) a logistic regression was performed to estimate the association of this adipokine with hypertension, the lower the plasma adiponectin values, the greater the association. A multivariate linear regression analysis adjusted for cardiometabolic factors showed that systolic blood pressure increased by 1.612 mm Hg for 1 microg/mL reduction in adiponectin plasma levels (P < 0.01). CONCLUSION: Our findings have shown that hypoadiponectinemia is associated with prehypertension in obese individuals of multiethnic origin. |
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Authors:
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Bruno M J Celoria; Virginia A Genelhu; Stenio Fernando Pimentel Duarte; Paula A S Delfraro; Emilio A Francischetti |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical cardiology Volume: 33 ISSN: 1932-8737 ISO Abbreviation: Clin Cardiol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-21 Completed Date: 2010-10-04 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: E61-5 Citation Subset: IM |
Affiliation:
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Hypertension Clinic, Laboratory of Clinical and Experimental Pathophysiology, School of Medicine, Rio de Janeiro State University, Rio de Janeiro, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood Adult Biological Markers / blood Blood Pressure* Blood Pressure Determination / instrumentation Body Mass Index Brazil / epidemiology Chi-Square Distribution Cross-Sectional Studies Down-Regulation Humans Hypertension / blood*, ethnology, physiopathology* Insulin / blood Insulin Resistance Linear Models Logistic Models Middle Aged Obesity / blood*, ethnology, physiopathology* Odds Ratio Radioimmunoassay Risk Assessment Risk Factors Sphygmomanometers |
| Chemical | |
Reg. No./Substance:
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0/ADIPOQ protein, human; 0/Adiponectin; 0/Biological Markers; 0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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