Document Detail


Hypnotic self administration: forced-choice versus single-choice.
MedLine Citation:
PMID:  9342777     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty-four men and women with insomnia, age 21-50 years, self administered hypnotics under a single-choice with placebo, single-choice with triazolam (0.25 mg), or forced-choice of placebo versus triazolam (0.25 mg) paradigm. Subjects received 4- sampling nights of placebo or triazolam in the single-choice conditions or 2 nights of each in the forced-choice condition. Then on 7 choice nights they could self administer a capsule, or not, in the single-choice conditions, or were required to choose one of two color-coded capsules in the forced-choice condition. In the single-choice conditions, subjects chose placebo 80% of nights and triazolam 77% of nights, while in the forced-choice condition triazolam was chosen on 86% of nights. Thus, the self administration of triazolam did not vary significantly between single or forced choice conditions, but that of placebo did. Placebo rate was high when it was the only alternative, but low when competing with triazolam. On sampling nights, compared to placebo, triazolam produced a significant increase in total sleep time, a reduction in latency to sleep, wake after sleep onset, and percentage stage 1 sleep. Triazolam, relative to placebo, also improved mood in the morning on some sampling nights. For subjects choosing capsules < 100% of opportunities (n = 14), on nights a capsule was chosen versus nights none was chosen (regardless of whether placebo or triazolam was the choice), self-ratings 30 min before bedtime on the Profile of Mood States vigor scale were significantly higher.
Authors:
T Roehrs; B Pedrosi; L Rosenthal; F Zorick; T Roth
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychopharmacology     Volume:  133     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-11-20     Completed Date:  1997-11-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  121-6     Citation Subset:  IM    
Affiliation:
Henry Ford Hospital, Sleep Disorders and Research Center, Detroit, MI 48202, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Affect / drug effects
Double-Blind Method
Female
Humans
Hypnotics and Sedatives / therapeutic use*
Male
Middle Aged
Self Administration
Sleep Initiation and Maintenance Disorders / drug therapy*
Sleep Stages / drug effects
Triazolam / therapeutic use*
Grant Support
ID/Acronym/Agency:
R01 DA05086/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Hypnotics and Sedatives; 28911-01-5/Triazolam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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