Document Detail

Hypnosis effect on carbon dioxide chemosensitivity.
MedLine Citation:
PMID:  3086046     Owner:  NLM     Status:  MEDLINE    
Hypnosis is an induced state of heightened suggestibility during which certain physiologic variables can be altered. To investigate if carbon dioxide (CO2) chemosensitivity could be blunted during this suggestible state, we measured hypercapnic ventilatory response (HCVR, delta VE/delta PaCO2), oxygen consumption (VO2), breathing pattern (VT and f), inspiratory flow rate (VT/Ti), and inspiratory timing (Ti/Ttot) in 20 healthy subjects. Mouth occlusion pressures (P0.1) were measured in the last nine subjects. Resting oxygen consumption and minute ventilation were measured during awake and hypnotic control states. The HCVR was measured spontaneously and with the suggestion to maintain normal ventilation during both awake and hypnotic conditions. It was found that without a change in metabolism, ventilatory responses to CO2 could be blunted both voluntarily, and to a greater degree, with hypnotic suggestion. These findings may have important implications in clinical settings in which patients suffer from marked dyspnea secondary to increased ventilatory chemosensitivity.
P Sato; M Sargur; R B Schoene
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chest     Volume:  89     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-07-16     Completed Date:  1986-07-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  828-31     Citation Subset:  AIM; IM    
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MeSH Terms
Carbon Dioxide / pharmacology*
Heart Rate / drug effects
Hypercapnia / physiopathology
Middle Aged
Oxygen Consumption / drug effects
Pulmonary Ventilation / drug effects
Respiration / drug effects*
Tidal Volume
Grant Support
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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