| Hypervitaminosis A syndrome: a paradigm of retinoid side effects. | |
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MedLine Citation:
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PMID: 3294938 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Retinoids have and will continue to revolutionize dermatologic therapy in a manner analogous to the development of topical corticosteroids. Isotretinoin, for example, has made nodulocystic scarring acne an eminently treatable condition. The dermatologic armamentarium now includes a powerful new agent, etretinate, which will radically change the approach to psoriasis (and other keratinizing disorders). Although each new retinoid is developed with the aim of maximizing specific therapeutic effects and minimizing toxicity, the fact remains that the major side effects of retinoid treatment are those of hypervitaminosis A syndrome. Optimal clinical utilization of new retinoids is best accomplished by an assessment of what is currently known about retinol absorption, metabolism and organ-specific effects, as well as by a thorough understanding of hypervitaminosis A syndrome. In this paper, hypervitaminosis A syndrome is reviewed as a paradigm of retinoid side effects. |
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Authors:
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A K Silverman; C N Ellis; J J Voorhees |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of the American Academy of Dermatology Volume: 16 ISSN: 0190-9622 ISO Abbreviation: J. Am. Acad. Dermatol. Publication Date: 1987 May |
Date Detail:
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Created Date: 1987-07-08 Completed Date: 1987-07-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7907132 Medline TA: J Am Acad Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1027-39 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Adult Biological Transport Child Chronic Disease Dose-Response Relationship, Drug Humans Hypervitaminosis A / complications, diagnosis, etiology*, metabolism Retinoids / adverse effects*, metabolism Tissue Distribution Vitamin A / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Retinoids; 11103-57-4/Vitamin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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