Document Detail


Hypervitaminosis A-induced liver fibrosis: stellate cell activation and daily dose consumption.
MedLine Citation:
PMID:  16448456     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypervitaminosis A-related liver toxicity may be severe and may even lead to cirrhosis. In the normal liver, vitamin A is stored in hepatic stellate cells (HSC), which are prone to becoming activated and acquiring a myofibroblast-like phenotype, producing large amounts of extracellular matrix. AIMS: In order to assess the relationship between vitamin A intake, HSC activation and fibrosis, we studied nine liver biopsies from patients belonging to a well-characterized series of 41 patients with vitamin A hepatotoxicity. METHODS: Fibrosis was underlined by Sirius-red staining, whereas activated HSC were immunohistochemically identified using an antibody against alpha smooth muscle actin. The volume density (Vv) of sinusoidal and total fibrosis and of sinusoidal and total activated HSC was quantified by the point-counting method. RESULTS: Morphology ranged from HSC hypertrophy and hyperplasia as the sole features to severe architectural distortion. There was a significant positive correlation between Vv of perisinusoidal fibrosis and the daily consumption of vitamin A (P=0.004). CONCLUSION: The close correlation between the severity of perisinusoidal fibrosis and the daily dose of the retinol intake suggests the existence of a dose-effect relationship.
Authors:
M-C Nollevaux; Y Guiot; Y Horsmans; I Leclercq; J Rahier; A P Geubel; C Sempoux
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Liver international : official journal of the International Association for the Study of the Liver     Volume:  26     ISSN:  1478-3223     ISO Abbreviation:  Liver Int.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-01     Completed Date:  2006-06-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101160857     Medline TA:  Liver Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  182-6     Citation Subset:  IM    
Affiliation:
Department of Pathology, Cliniques universitaires Saint Luc, University of Louvain, Brussels, Belgium. marie-cecile.nollevaux@mont.ucl.ac.be
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MeSH Terms
Descriptor/Qualifier:
Actins / metabolism
Adult
Aged
Biological Markers / metabolism
Cell Enlargement / drug effects
Female
Humans
Hyperplasia / chemically induced,  pathology
Hypervitaminosis A / chemically induced*,  pathology
Immunohistochemistry
Kupffer Cells / drug effects*,  metabolism,  pathology
Liver / drug effects,  metabolism,  pathology
Liver Cirrhosis / chemically induced*,  pathology
Male
Middle Aged
Vitamin A / adverse effects*
Chemical
Reg. No./Substance:
0/Actins; 0/Biological Markers; 11103-57-4/Vitamin A

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