| Hypervitaminosis a in early human pregnancy and malformations of the central nervous system. | |
| | |
MedLine Citation:
|
PMID: 665178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A case of malformations of the fetal central nervous system following hypervitaminosis A in early pregnancy is reported. The mother was treated with 150 000 IU vitamin A daily during gestation days 19 to 40. Determination of urinary oestriol carried out in the 42nd week of pregnancy revealed a very low excretion (4.2-6.6) mumol/24 h). Induced delivery resulted in a microcephalic child who died after 18 min. The child had multiple malformations of the central nervous system and very small adrenal glands (1.5 g; normal 11 +/- 4 g). The very low urinary oestriol excretion is well explained by the hypoplastic adrenals, which in turn can be related to insufficient ACTH stimulation, a condition similar to anencephaly. The malformations shown in the present case are considered to be related to the high doses of vitamin A given to the mother, and the authors wish to warn against uncritical use of high doses of vitamin A in whomen of childbearing age. |
| | |
Authors:
|
L Stånge; K Carlström; M Eriksson |
Related Documents
:
|
20483528 - Maternal urological problems in pregnancy. 2737598 - Similarities in maximal biliary bilirubin output in the normal rat after administration... 20493248 - Increase in male fetal deaths in japan and congenital anomalies of the kidney and urina... 12797028 - Spontaneous remission of urinary tract obstruction and ascites in a fetus with posterio... 1726038 - Alpha-fetoprotein and renal dysfunction of the fetus. 9194628 - Reduction in the size of a uterine leiomyoma following discontinuation of an estrogen-p... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Acta obstetricia et gynecologica Scandinavica Volume: 57 ISSN: 0001-6349 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 1978 |
Date Detail:
|
Created Date: 1978-08-14 Completed Date: 1978-08-14 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: SWEDEN |
Other Details:
|
Languages: eng Pagination: 289-91 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abnormalities, Multiple
/
chemically induced Adrenal Glands / abnormalities Adult Estriol / urine Female Humans Maternal-Fetal Exchange Microcephaly / chemically induced* Placenta / enzymology Pregnancy Pregnancy Complications* Sulfatases / metabolism Vitamin A / adverse effects* |
| Chemical | |
Reg. No./Substance:
|
11103-57-4/Vitamin A; 50-27-1/Estriol; EC 3.1.6.-/Sulfatases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Treatment of menopausal oestrogen deficiency symptoms in hysterectomised women by means of 17beta-oe...
Next Document: Organ culture studies on human skin and cholesteatoma epithelium. Contact with connective tissue and...