Document Detail

Hyperventilation challenge test in panic disorder and depression with panic attacks.
MedLine Citation:
PMID:  11740975     Owner:  NLM     Status:  MEDLINE    
Our aim was to determine whether panic disorder (PD) patients, major depressive patients without panic attacks (MD) and major depressive patients with panic attacks (MDP) respond similarly to hyperventilation challenge tests. We randomly selected 35 PD patients, 33 MDP patients, 27 MD patients and 30 normal volunteers with no family history of anxiety or mood disorder. The patients had not been treated with psychotropic drugs for at least 1 week. They were induced to hyperventilate (30 breaths/min) for 4 min, and anxiety was assessed before and after the test. A total of 16 (45.7%) PD patients, 12 (36.4%) MDP patients, four (11.1%) MD patients, and two (6.7%) normal volunteers had a panic attack after hyperventilating. The PD and MDP patients were significantly more responsive to hyperventilation than the MD patients and the normal volunteers. The MD patients had a significantly lower heart-rate response to the test than all the other groups. There is growing evidence that PD patients are more sensitive to the vasoconstrictive effects on basilar arterial blood flow caused by hyperventilation-induced hypocapnia than are comparison subjects. Our data suggest that there is an association between panic attacks and hyperreactivity to an acute hyperventilation challenge test.
A E Nardi; A M Valença; I Nascimento; W A Zin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychiatry research     Volume:  105     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-13     Completed Date:  2002-02-26     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  57-65     Citation Subset:  IM    
Laboratory of Panic and Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, R. Visconde de Pirajá, 407/702, RJ-22410-003, Rio de Janeiro, Brazil.
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MeSH Terms
Arousal / physiology*
Basilar Artery / physiopathology
Depressive Disorder, Major / diagnosis*,  physiopathology,  psychology
Heart Rate / physiology
Hyperventilation / physiopathology*,  psychology
Middle Aged
Panic / physiology*
Panic Disorder / diagnosis*,  physiopathology,  psychology
Reference Values
Risk Factors
Vasoconstriction / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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