Document Detail

Hypervascular thyroid nodules on time-resolved MR angiography at 3 T: radiologic-pathologic correlation.
MedLine Citation:
PMID:  18356417     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Detection of a thyroid nodule, either incidental or as a result of related symptomatology, is an extremely common event, often inducing considerable uncertainty regarding the requirement for and best means of further investigation. Whereas tissue sampling represents the sole means of true characterization of these lesions, a number of imaging characteristics have been suggested as potential indicators of the presence of malignancy. The potential value of time-resolved MR angiography, whereby a minimal dose of i.v. contrast agent is dynamically depicted during the first pass of the bolus through the various compartments of circulation, has recently been realized, particularly so with regard to supraaortic angiography. However, it is not uncommon during such temporal imaging to identify focal hyperenhancing thyroid nodules, the significance of which has not previously been described in the literature. We describe the frequency of occurrence and potential significance of this finding, using pathologic correlation where available.
CONCLUSION: The prevalence of malignancy in incidentally detected focal hyperenhancing thyroid parenchymal nodules during time-resolved MR angiography is significant, representing 8.3% (1/12) of patients for whom cytologic correlation was available. Further investigation is certainly warranted when encountering such a lesion in clinical practice, particularly because it appears as though time-resolved MR angiography is of no value in the pathologic discrimination of such incidentally identified lesions.
Derek G Lohan; Anderanik Tomasian; Roya Saleh; Mayil Krishnam; J Paul Finn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  190     ISSN:  1546-3141     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-21     Completed Date:  2008-05-06     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  W255-60     Citation Subset:  AIM; IM    
Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Peter V. Ueberroth Bldg., Ste. 3371, 10945 Le Conte Ave., Los Angeles, CA 90095-7206, USA.
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MeSH Terms
Aged, 80 and over
Contrast Media / administration & dosage
Gadolinium DTPA / administration & dosage,  diagnostic use
Imaging, Three-Dimensional
Injections, Intravenous
Magnetic Resonance Angiography / methods*
Middle Aged
Neovascularization, Pathologic / diagnosis*,  pathology
Retrospective Studies
Thyroid Neoplasms / diagnosis*,  epidemiology,  pathology
Thyroid Nodule / diagnosis*,  epidemiology,  pathology
Reg. No./Substance:
0/Contrast Media; 80529-93-7/Gadolinium DTPA

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