Document Detail


Hypervariable digital DNA codes for human paternal lineages: MVR-PCR at the Y-specific minisatellite, MSY1 (DYF155S1).
MedLine Citation:
PMID:  9499417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We describe the first haploid minisatellite, the human Y chromosome-specific locus, MSY1. It consists of an array of 48-114 AT-rich 25 bp repeats of at least five different variant types. A minisatellite variant repeat PCR (MVR-PCR) system gives Y-specific DNA codes, with a virtual heterozygosity of 99.9%, making MSY1 by far the single most variable locus on the Y. African populations contain the most diverged MSY1 structures. MSY1 is the only Y-chromosomal system where the characteristics of large numbers of mutations can be studied in detail: it provides a uniquely powerful tool both for the investigation of mutation in a haploid system, and for the dating of paternal lineages.
Authors:
M A Jobling; N Bouzekri; P G Taylor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Human molecular genetics     Volume:  7     ISSN:  0964-6906     ISO Abbreviation:  Hum. Mol. Genet.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-05-12     Completed Date:  1998-05-12     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  9208958     Medline TA:  Hum Mol Genet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  643-53     Citation Subset:  IM    
Affiliation:
Department of Genetics, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK. maj4@leicester.ac.uk
Data Bank Information
Bank Name/Acc. No.:
GENBANK/Y07727;  Y07728
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MeSH Terms
Descriptor/Qualifier:
Africa
Americas
Asia
Base Sequence
Europe
Genetic Variation
Haploidy
Haplotypes
Humans
Minisatellite Repeats* / genetics
Molecular Sequence Data
Mutation
Pacific Islands
Polymerase Chain Reaction
Y Chromosome / genetics*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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