Document Detail

Hyperuricemia and locomotor activity in developing rats.
MedLine Citation:
PMID:  2813475     Owner:  NLM     Status:  MEDLINE    
This research was motivated by the previous finding that serum uric acid levels correlate with symptoms of hyperactivity in normal children. We attempted, therefore, to investigate this relationship in an animal model. Dose and time relationships between allantoxanamide-induced heightened serum uric acid and locomotor activity were investigated. A dose- and time-dependent relationship was shown between serum uric acid levels and allantoxanamide. Those doses of allantoxanamide which elevated serum uric acid produced time-dependent changes in locomotor activity. In the first two hours following injection, activity increased relative to controls, in the next two-hour block activity decreased, only to rise again above control levels in the third two-hour period. The possible role of uric acid and allantoxanamide are discussed in relation to these complex changes in activity.
C M Barrera; R E Hunter; W P Dunlap
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  33     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-12-19     Completed Date:  1989-12-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  367-9     Citation Subset:  IM    
V.A. Medical Center/Research, New Orleans, LA 70146.
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MeSH Terms
Dose-Response Relationship, Drug
Motor Activity / physiology*
Oxonic Acid / analogs & derivatives,  pharmacology*
Rats, Inbred Strains
Time Factors
Triazines / pharmacology*
Urate Oxidase / antagonists & inhibitors*
Uric Acid / blood*
Reg. No./Substance:
0/Triazines; 69-93-2/Uric Acid; 69391-08-8/allantoxanamide; 937-13-3/Oxonic Acid; EC Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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