| Hyperuricemia influences chronic cyclosporine nephropathy. | |
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MedLine Citation:
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PMID: 18261576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The observation that long-standing hyperuricemia is associated with chronic tubulointerstitial disease, afferent arteriolopathy, intrarenal vasoconstriction, and increased vascular resistance raises the hypothesis that hyperuricemia might contribute to chronic cyclosporine (CsA) nephropathy. The aim of the present study was to investigate the effect of hyperuricemia on chronic CsA nephropathy. METHODS: Patients who were treated with CsA-based immunsuppressive regimens and underwent a renal biopsy were enrolled in this case-control study. We retrospectively obtained posttransplant baseline serum creatinine, uric acid (UA), mean serum UA, and creatinine values 3 months prior to biopsy. CsA trough levels, mean blood pressure, diuretic and antihypertensive treatment were recorded. Biopsy specimens showing CsA nephropathy (n = 34) were revaluated by a pathologist to score CsA nephropathy according to recent quantitative criteria for calcineurin inhibitor arteriolopathy as proposed by M.J. Mihatsch. RESULTS: As compared with the non-CsA nephropathy group, recipient and donor ages, donor origin and cold ischemia times were similar for the CsA nephropathy group (P > .05). Mean CsA doses, CsA trough (C(0)), and C(2) levels were not different between the groups (P > .05). Systolic and diastolic blood pressure, glomerular filtration rate, diuretic usage, and antihypertensive treatment were also similar in CsA nephropathy and non-CsA nephropathy groups (P > .05). Mean serum UA level within 3 months prior to biopsy in the CsA nephropathy and non-CsA nephropathy groups were 7.5 +/- 1.4 mg/dL versus 5.7 +/- 1.4 mg/dL, respectively (P < .001). CONCLUSION: Hyperuricemia seems to exacerbate CsA-induced nephropathy. |
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Authors:
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F Saglam; A Celik; S Sarioglu; C Cavdar; A Sifil; H Gulay; T Camsari |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Transplantation proceedings Volume: 40 ISSN: 0041-1345 ISO Abbreviation: Transplant. Proc. Publication Date: 2008 Jan-Feb |
Date Detail:
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Created Date: 2008-02-11 Completed Date: 2008-05-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
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Languages: eng Pagination: 167-70 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Dokuz Eylul University, School of Medicine, Balcova, Izmir. funda.saglam@dcu.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antihypertensive Agents / therapeutic use Chronic Disease Cyclosporine / adverse effects* Female Humans Hyperuricemia / etiology, physiopathology* Immunosuppressive Agents / adverse effects Kidney Transplantation / adverse effects*, pathology Male Middle Aged Retrospective Studies Uric Acid / blood |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Immunosuppressive Agents; 59865-13-3/Cyclosporine; 69-93-2/Uric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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