Document Detail

Hyperuricemia induced by some antihypertensives and uricosuric drugs in oxonate-treated rats.
MedLine Citation:
PMID:  7241859     Owner:  NLM     Status:  MEDLINE    
Effects of antihypertensive and uricosuric drugs were studied on the plasma and urinary levels of uric acid in oxonate-treated rats. We made use of animals with a catheterized aorta to successfully collect blood samples and this procedure simplified the evaluation of progressive changes of plasma uric acid, under successive loading with potassium oxonate. The plasma uric acid level of the oxonate-treated rats was increased even with a single administration of diuretic chlorothiazides, furosemide, diazoxide and also uricosuric drugs such as tienilic acid and probenecid. On the other hand, a wellmaintained plasma uric acid level was also produced by exogenously administered uric acid in rats which had been given allopurinol and potassium oxonate. Diazoxide, tienilic acid and probenecid increased the plasma uric acid, while diuretic chlorothiazides did not. Furosemide tended to decrease the plasma uric acid level at the early stage of administration to rats treated with allopurinol, oxonate and uric acid, but increased these levels several hours later when the effect was studied by uric acid loading test wit rats treated with allopurinol and oxonate. These effects also appeared as changes in the urine-excreted uric acid. Thus, the oxonate-treated rats demonstrated an acutely induced hyperuricemia not only with certain antihypertensives, but also with uricosuric drugs. The utility of these procedures for evaluating the hyperuricemic and uricosuric effects of drugs is discussed.
Y Yonetani; M Ishii; K Iwaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  30     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-08-20     Completed Date:  1981-08-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  829-40     Citation Subset:  IM    
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MeSH Terms
Allantoin / blood
Antihypertensive Agents / adverse effects*
Models, Biological
Oxonic Acid / pharmacology*
Stimulation, Chemical
Triazines / pharmacology*
Uric Acid / blood*,  urine
Uricosuric Agents / adverse effects*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Triazines; 0/Uricosuric Agents; 69-93-2/Uric Acid; 937-13-3/Oxonic Acid; 97-59-6/Allantoin

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