Document Detail


Hyperuricemia and gout: new insights into pathogenesis and treatment.
MedLine Citation:
PMID:  17922673     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over the past decade, significant advances have been made regarding the pathogenesis, clinical implications, and treatment of hyperuricemia. While physicians have understood for at least a century that uric acid causes gout, we are now beginning to address the question of why hyperuricemia exists and the mechanisms by which uric acid acts to stimulate inflammation. This review focuses on (1) previously unknown biological roles of uric acid; (2) why the loss of the uricase gene and resultant hyperuricemia may have provided an evolutionary advantage to primates and, in particular, to humans; (3) the molecular effects of uric acid on inflammatory cells; and (4) novel antihyperuricemic agents currently under study.
Authors:
Michael H Pillinger; Pamela Rosenthal; Aryeh M Abeles
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Bulletin of the NYU hospital for joint diseases     Volume:  65     ISSN:  1936-9719     ISO Abbreviation:  -     Publication Date:  2007  
Date Detail:
Created Date:  2007-10-09     Completed Date:  2008-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101300541     Medline TA:  Bull NYU Hosp Jt Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  215-21     Citation Subset:  IM    
Affiliation:
New York University School of Medicine and Division of Rheumatology, NYU Hospital for Joint Diseases, New York, NY 10003, USA. michael.pillinger@med.nyu.edu
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / therapeutic use
Animals
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Colchicine / therapeutic use
Gout / immunology*,  prevention & control*
Gout Suppressants / therapeutic use*
Humans
Hyperuricemia / immunology*,  prevention & control*
Interleukin 1 Receptor Antagonist Protein / therapeutic use
Thiazoles / therapeutic use
Urate Oxidase / therapeutic use
Uric Acid / immunology*
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Gout Suppressants; 0/Interleukin 1 Receptor Antagonist Protein; 0/Thiazoles; 144060-53-7/febuxostat; 64-86-8/Colchicine; 69-93-2/Uric Acid; EC 1.7.3.3/Urate Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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