Document Detail

Hyperuricemia associated with high cardiac event rates in the elderly with chronic heart failure.
MedLine Citation:
PMID:  16764328     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Congestive heart failure (CHF) is the major cause of death and hospitalization in the elderly population. Simple markers that can be measured anywhere at low cost are necessary to identify patients at high risk. Recent studies have reported that hyperuricemia is a prognostic marker for CHF. However, it is not yet known whether serum levels of uric acid may provide prognostic information in the elderly population. Therefore, this study tried to identify the clinical characteristics of elderly CHF patients (+/-70 years) in our institution and to evaluate whether uric acid levels can effectively estimate the prognosis for elderly CHF patients. METHODS AND RESULTS: Uric acid levels were analyzed in 247 CHF patients, and patients were followed up for 451 +/- 235 days (mean +/- SD). Elderly CHF patients aged > or =70 years (123 patients) had higher rate of hypertension, lower current smoking rate and higher uric acid levels than those aged < 70 years (124 patients). There were 72 cardiac events including cardiac deaths and readmissions for worsening CHF. Multivariate analysis with the Cox proportional hazard model showed that uric acid was the only independent predictor of cardiac events (hazard ratio 1.544, 95% confidence interval 1.215-2.582, p < 0.0001) in the elderly with CHF. The highest quartile of uric acid level was associated with the highest risk of cardiac events (a 4.45-fold compared to the lowest quartile). Kaplan-Meier analysis revealed that uric acid levels effectively risk stratified elderly CHF patients for cardiac events. CONCLUSIONS: These findings suggest that measurement of uric acid levels in elderly CHF patients may add valuable prognostic information to predict cardiac events.
Takeshi Niizeki; Yasuchika Takeishi; Takanori Arimoto; Hidenobu Okuyama; Naoki Nozaki; Osamu Hirono; Yuichi Tsunoda; Tetsu Watanabe; Joji Nitobe; Takehiko Miyashita; Hiroki Takahashi; Yo Koyama; Isao Kubota
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiology     Volume:  47     ISSN:  0914-5087     ISO Abbreviation:  J Cardiol     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-06-12     Completed Date:  2006-06-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  219-28     Citation Subset:  IM    
Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata.
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MeSH Terms
Biological Markers / blood
Heart Failure / blood*,  complications,  physiopathology*
Hyperuricemia / complications*,  physiopathology
Middle Aged
Multivariate Analysis
Uric Acid / blood
Reg. No./Substance:
0/Biological Markers; 69-93-2/Uric Acid

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