Document Detail

Hyperuricemia as a predictor of hypertension in a screened cohort in Okinawa, Japan.
MedLine Citation:
PMID:  15824465     Owner:  NLM     Status:  MEDLINE    
Several epidemiological studies have shown a positive association between serum uric acid levels and the risk of hypertension. However, subjects in these studies were mostly men, or were incompletely examined for lifestyle-related variables. We prospectively examined the relation between hyperuricemia and the risk of developing hypertension with consideration for alcohol consumption and smoking habits in a large screened cohort of men and women. A total of 4,489 individuals (2,927 men and 1,562 women) who did not have hypertension and were not currently using antihypertensive medication were examined at the Okinawa General Health Maintenance Association in 1977. Subjects were re-examined in 2000. Hyperuricemia was defined as a serum uric acid level >or=7.0 mg/dl in men and >or=6.0 mg/dl in women. Hypertension was defined as systolic blood pressure (SBP) >or=140 mmHg, and/or diastolic blood pressure (DBP) >or=90 mmHg. A total of 289 subjects (201 men and 88 women) were hypertensive (SBP >or=140 mmHg, and/or DBP >or=90 mmHg) in 2000. Multivariate analysis was performed for development of hypertension in hyperuricemic subjects, adjusted for age, family history of hypertension, alcohol consumption, cigarette smoking, obesity, hypercholesterolemia, hypertriglyceridemia, low high-density lipoprotein cholesterol, and diabetes mellitus. The adjusted odds ratio (95% confidence interval) in men was 1.48 (1.08-2.02) and in women was 1.90 (1.03-3.51) (p <0.05, respectively). The results showed hyperuricemia to be a new predictor of hypertension development in both men and women.
Kazufumi Nagahama; Taku Inoue; Kunitoshi Iseki; Takashi Touma; Kozen Kinjo; Yusuke Ohya; Shuichi Takishita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  27     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2005-04-12     Completed Date:  2005-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  835-41     Citation Subset:  IM    
Department of Cardiovascular Medicine, Nephrology and Neurology, Faculty of Medicine, University of the Ryukyus, Nakagami-gun, Okinawa, Japan.
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MeSH Terms
Aged, 80 and over
Alcohol Drinking / epidemiology
Blood Pressure
Cohort Studies
Hypertension, Renal / epidemiology*
Hyperuricemia / epidemiology*
Insulin Resistance
Japan / epidemiology
Mass Screening
Metabolic Syndrome X / epidemiology
Middle Aged
Multivariate Analysis
Predictive Value of Tests
Prospective Studies
Risk Factors
Smoking / epidemiology

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