Document Detail


Hyperuricemia and incident heart failure.
MedLine Citation:
PMID:  19919980     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Hyperuricemia, a known correlate of oxidative stress, is a marker for adverse prognosis among individuals with heart failure. However, the relationship between hyperuricemia and the risk for incidence of heart failure in a community-based population has not been studied.
METHODS AND RESULTS: We prospectively analyzed the relationship between serum uric acid concentration at baseline and subsequent heart failure among the participants of the Framingham Offspring cohort (n=4912; mean baseline age, 36 years; 52% women). By using Cox regressions, we calculated the risk of heart failure with increasing serum uric acid after adjusting for sex, age, smoking, body mass index, renal dysfunction, diuretics, systolic blood pressure, valvular heart disease, diabetes, alcohol, and use of antihypertensive medications. The incidence rates of heart failure were approximately 6-fold higher among those at the highest quartile of serum uric acid (>6.3 mg/dL) compared with those at the lowest quartile (<3.4 mg/dL). The adjusted hazard ratio for the highest quartile of serum uric acid compared with the lowest was 2.1 (1.04 to 4.22). The relationship between hyperuricemia and heart failure was found in participants without metabolic syndrome and other subgroups as well.
CONCLUSIONS: Hyperuricemia is a novel, independent risk factor for heart failure in a group of young general community dwellers. This has implications for development of preventive strategies for heart failure.
Authors:
Eswar Krishnan
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-08-06
Journal Detail:
Title:  Circulation. Heart failure     Volume:  2     ISSN:  1941-3297     ISO Abbreviation:  Circ Heart Fail     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-20     Completed Date:  2009-12-03     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  101479941     Medline TA:  Circ Heart Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  556-62     Citation Subset:  IM    
Affiliation:
Department of Medicine, Stanford University School of Medicine, Stanford, California, USA. e.krishnan@stanford.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
Female
Heart Failure / blood,  epidemiology,  etiology*
Humans
Hyperuricemia / blood,  complications*,  epidemiology
Incidence
Kaplan-Meier Estimate
Male
Middle Aged
Prognosis
Proportional Hazards Models
Prospective Studies
Risk Assessment
Risk Factors
Time Factors
Uric Acid / blood*
Young Adult
Grant Support
ID/Acronym/Agency:
KL2 RR024154/RR/NCRR NIH HHS; KL2 RR024154-01/RR/NCRR NIH HHS; KL2 RR024154-01/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 69-93-2/Uric Acid
Comments/Corrections

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