| Hyperuricaemia predicts poor outcome in patients with mild to moderate chronic heart failure. | |
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MedLine Citation:
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PMID: 16782216 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In severe chronic heart failure (CHF) elevated serum levels of uric acid (UA) predict poor survival. This study investigates whether hyperuricaemia (defined as serum UA level > or = 6.5 mg/dL) extends its prognostic value on population with less advanced CHF. METHODS: We studied 119 consecutive patients with stable, mild-moderate CHF (88 men, age: 64+/-11 years, NYHA class I/II/III: 9/65/45, LVEF: 32+/-8%). RESULTS: Serum UA level (mean: 6.2+/-2.0 mg/dL, range: 2.0-16.2 mg/dL) increased in parallel to CHF severity expressed as NYHA class (4.9+/-1.1 vs. 5.7+/-1.5 vs. 7.2+/-2.4 mg/dL, NYHA I vs. II vs. III; NYHA I, II vs. III, p<0.01), inversely correlated with peak oxygen consumption (r=-0.39, p<0.01) and LVEF (r=-0.31, p<0.01), but not with renal function (expressed as creatinine clearance calculated from Cockcroft-Gault formula; r=-0.14, p>0.1), and predicted inflammatory status as evidenced by the correlation with C-reactive protein (r=0.31, p=0.003). Hyperuricaemia was detected in 48 (40%) patients. During follow-up (mean: 580+/-209 days, > 18 months in all survivors), 27 (23%) patients died. Hyperuricaemia was related to impaired survival in univariate (HR 2.8, 95%CI: 1.3-6.1, p=0.01) and multivariate analyses (adjusted for NYHA class and impaired renal function--the only mortality predictors in this population; p<0.05). The 18-month survival for CHF patients with hyperuricaemia was 71% (95% CI: 58-84%) vs. 89% (95% CI: 81-96%) in those with normal UA level (p=0.01). CONCLUSION: In patients with mild-moderate CHF, hyperuricaemia predicts exercise intolerance and inflammatory activation and is strongly and independently related to poor prognosis. Whether elevated serum UA level may become a novel therapeutic target in CHF, deserves further studies. |
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Authors:
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Ewa A Jankowska; Beata Ponikowska; Jacek Majda; Robert Zymlinski; Mieczyslaw Trzaska; Krzysztof Reczuch; Ludmila Borodulin-Nadzieja; Waldemar Banasiak; Piotr Ponikowski |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-06-19 |
Journal Detail:
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Title: International journal of cardiology Volume: 115 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-29 Completed Date: 2007-04-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 151-5 Citation Subset: IM |
Affiliation:
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Cardiology Department, Military Hospital, ul. Weigla 5, 50-981 Wroclaw, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chronic Disease Female Heart Failure / blood, complications* Humans Hyperuricemia / complications* Male Middle Aged Prognosis Severity of Illness Index Uric Acid / blood |
| Chemical | |
Reg. No./Substance:
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69-93-2/Uric Acid |
| Comments/Corrections | |
Comment In:
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Int J Cardiol. 2007 Feb 7;115(2):156-8
[PMID:
16844250
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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