Document Detail


Hypertrophic reprogramming of the left ventricle: translation to the ECG.
MedLine Citation:
PMID:  22999493     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypertrophic growth of the heart occurs in many clinical scenarios, and it confers substantially increased risk of untoward sequelae. Among them, transition to ventricular dilation, wall thinning, contractile dysfunction, and a clinical syndrome of heart failure are paramount. Left ventricular hypertrophy (LVH) is typically diagnosed by either electrocardiography or echocardiography. However, these two means of assessing hypertrophic transformation of the left ventricle can sometimes disagree. At one level, this may not be surprising as the two methodologies are based on entirely divergent signals: electrical potential between two places on the surface of the skin and ultrasound energy reflected from the ventricle itself. Echocardiography is an effective means of assessing ventricular mass, which is a cardinal feature of LVH. Importantly, however, LVH is characterized by a wide range of remodeling events beyond simple increases in muscle mass. Electrocardiographic changes in LVH are reflective of the electrophysiological aspects of hypertrophic transformation. Here, I present an overview of the complex biology of left ventricular hypertrophy with an eye toward enhancing our understanding of its ECG manifestations.
Authors:
Joseph A Hill
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-09-19
Journal Detail:
Title:  Journal of electrocardiology     Volume:  45     ISSN:  1532-8430     ISO Abbreviation:  J Electrocardiol     Publication Date:    2012 Nov-Dec
Date Detail:
Created Date:  2012-10-29     Completed Date:  2013-05-14     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  0153605     Medline TA:  J Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  624-9     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Affiliation:
Department of Internal Medicine, Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8573, USA. joseph.hill@utsouthwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Electrocardiography / methods*
Heart Conduction System / physiopathology*
Humans
Hypertrophy, Left Ventricular / complications,  diagnosis*,  physiopathology*
Models, Cardiovascular*
Ventricular Dysfunction, Left / diagnosis*,  etiology,  physiopathology*
Grant Support
ID/Acronym/Agency:
HL-075173/HL/NHLBI NIH HHS; HL-080144/HL/NHLBI NIH HHS; HL-090842/HL/NHLBI NIH HHS; P30 HL101254/HL/NHLBI NIH HHS; R01 HL075173/HL/NHLBI NIH HHS; R01 HL090842/HL/NHLBI NIH HHS
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