Document Detail

Hypertrophic pyloric stenosis and pulmonary hypertension in a neonate. A common mechanism?
MedLine Citation:
PMID:  19302103     Owner:  NLM     Status:  MEDLINE    
Nitric oxide (NO) is an important mediator of biological functions. Absence or shortage of NO plays a role in the pathogenesis of both hypertrophic pyloric stenosis and persistent pulmonary hypertension. We present a neonate diagnosed with pulmonary hypertension after birth caused by meconium-aspiration syndrome eventually treated with extracorporal membrane oxygenation followed by hypertrophic pyloric stenosis for which a pyloromyotomy was performed. In conclusion, the association of pulmonary hypertension and pyloric stenosis has not been described before and may be explained by a lowered plasma concentration of arginine leading to deficient NO synthesis in the affected organ systems.
A G A Brouwers; C M J A Waals-van de Wal
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-03-19
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  98     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-27     Completed Date:  2009-08-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1064-5     Citation Subset:  IM    
Department of Paediatric Intensive Care, Academic Hospital Maastricht, P. Debyelaan 25, Maastricht, The Netherlands.
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MeSH Terms
Extracorporeal Circulation
Hypertension, Pulmonary / complications*,  diagnosis,  therapy
Infant, Newborn
Meconium Aspiration Syndrome / complications,  diagnosis,  therapy
Pyloric Stenosis, Hypertrophic / complications*,  diagnosis,  surgery
Pylorus / surgery
Respiration, Artificial

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