Document Detail


Hypertrophic osteoarthropathy caused by PGE1 in a patient with congestive heart failure during cardiac rehabilitation.
MedLine Citation:
PMID:  12060968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Continuous chronic drug infusion with PGE1 via a portable pump and neuromuscular electrical stimulation (NMES) help to improve the quality of life in patients with severe chronic heart failure waiting for a donor heart, as both treatments can be performed at home. We report a 56-year-old woman suffering from severe chronic heart failure, who was referred for a cardiac rehabilitation program because of progressive muscle weakness and weight loss. Due to her underlying heart disease she was unable to perform voluntary exercise. NMES of both knee extensor muscles was started. Under simultaneous chronic drug infusion with PGE1 via a portable pump the patient developed clinical signs of hypertrophic osteoarthropathy, which prevented her from continuing the rehabilitation program. X-ray examinations and bone scans concurred with the diagnosis of secondary hypertrophic osteoarthropathy. After the PGE1 dose had been reduced, the clinical signs of the osteoarthropathy resolved and the patient was able to continue the rehabilitation program with no difficulty. This case report underlines the importance of being aware of the potential side effects of modern cardiac drugs in the complex treatment of patients waiting for a donor heart.
Authors:
Richard Crevenna; Michael Quittan; Martin Hülsmann; Günther F Wiesinger; Mohammad Y Keilani; Franz Kainberger; Thomas Leitha; Veronika Fialka-Moser; Richard Pacher
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Wiener klinische Wochenschrift     Volume:  114     ISSN:  0043-5325     ISO Abbreviation:  Wien. Klin. Wochenschr.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-06-13     Completed Date:  2002-10-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  21620870R     Medline TA:  Wien Klin Wochenschr     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  115-8     Citation Subset:  IM    
Affiliation:
Department of Physical Medicine and Rehabilitation, General Hospital Vienna, University of Vienna, Austria. richard.crevenna@univie.ac.at
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MeSH Terms
Descriptor/Qualifier:
Alprostadil / administration & dosage,  adverse effects*
Bone and Bones / drug effects,  radionuclide imaging
Chronic Disease
Combined Modality Therapy
Female
Heart Failure / rehabilitation*
Heart Transplantation
Humans
Infusion Pumps
Middle Aged
Muscle Weakness / rehabilitation
Osteoarthropathy, Secondary Hypertrophic / chemically induced*,  radionuclide imaging
Transcutaneous Electric Nerve Stimulation
Waiting Lists
Chemical
Reg. No./Substance:
745-65-3/Alprostadil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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