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Hypertrophic obstructive cardiomyopathy: hemodynamic improvement with intravenous verapamil.
MedLine Citation:
PMID:  15227134     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
We report the reduction in left ventricular outflow tract gradient following the intravenous administration of verapamil to two pediatric patients with hypertrophic obstructive cardiomyopathy. Traditional therapy with beta adrenergic antagonists was relatively contraindicated in both patients. In a 15-year-old patient, the left ventricular outflow tract gradient decreased from 160 torr, at rest, to 45 torr during the verapamil infusion. In a 3-year-old boy, there was a reduction in the left ventricular outflow tract gradient from 60 torr, under basal conditions, to 10 torr during the intravenous verapamil infusion. We believe that verapamil may be effective in reducing the left ventricular outflow tract gradient in some pediatric patients with hypertrophic obstructive cardiomyopathy and may be useful in treating selected patients with this disorder.
Authors:
S J Roth; C B Porter; L A Latson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital     Volume:  10     ISSN:  0730-2347     ISO Abbreviation:  Tex Heart Inst J     Publication Date:  1983 Jun 
Date Detail:
Created Date:  2004-06-30     Completed Date:  2005-02-03     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8214622     Medline TA:  Tex Heart Inst J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  177-81     Citation Subset:  -    
Affiliation:
The Lillie Frank Abercrombie Section of Cardiology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
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