Document Detail

Hypertrophic feline muscular dystrophy: diagnostic overview and a novel immunohistochemical diagnostic method using formalin-fixed tissue.
MedLine Citation:
PMID:  21558128     Owner:  NLM     Status:  MEDLINE    
This paper describes a case of hypertrophic feline muscular dystrophy (HFMD) in the UK. The cat under investigation died unexpectedly following routine vaccination, and postmortem investigation revealed myopathy, particularly affecting the diaphragm as well as multiple skeletal muscles. The right lung lobes were also partially collapsed and this was considered secondary to the effect of the muscular dystrophy. Pathological and immunohistochemical findings are described, macroscopic and microscopic findings are compared with other recorded cases in the literature and a diagnostic overview of HFMD is given. Possible causes of death are also discussed and a novel immunohistochemical method of demonstrating dystrophin deficiency using formalin-fixed tissue is described.
A S Blunden; S Gower
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2011-05-09
Journal Detail:
Title:  The Veterinary record     Volume:  168     ISSN:  2042-7670     ISO Abbreviation:  Vet. Rec.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-16     Completed Date:  2011-08-24     Revised Date:  2012-05-10    
Medline Journal Info:
Nlm Unique ID:  0031164     Medline TA:  Vet Rec     Country:  England    
Other Details:
Languages:  eng     Pagination:  510     Citation Subset:  IM    
Animal Health Trust, Lanwades Park, Newmarket, Suffolk, UK.
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MeSH Terms
Cat Diseases / diagnosis,  genetics,  pathology*
Dystrophin / analysis,  deficiency*
Fatal Outcome
Hypertrophy / diagnosis,  genetics,  pathology,  veterinary
Immunohistochemistry / veterinary*
Muscular Dystrophy, Animal / diagnosis,  genetics,  pathology*
Reg. No./Substance:
Comment In:
Vet Rec. 2011 May 14;168(19):507-8   [PMID:  21571851 ]

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